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regulatory cells. Blood. (2006) 108:253–61. doi: 10.1182/blood-2005-11-4567 be construed as a potential conflict of interest.
130. Zanin-Zhorov A, Ding Y, Kumari S, Attur M, Hippen KL,
Brown M, et al. Protein kinase C- mediates negative feedback on Copyright © 2019 Luque-Campos, Contreras-López, Jose Paredes-Martínez, Torres,
regulatory T cell function. Science. (2010) 328:372–6. doi: 10.1126/ Bahraoui, Wei, Espinoza, Djouad, Elizondo-Vega and Luz-Crawford. This is an
science.1186068 open-access article distributed under the terms of the Creative Commons Attribution
131. Nie H, Zheng Y, Li R, Guo TB, He D, Fang L, et al. Phosphorylation of FOXP3 License (CC BY). The use, distribution or reproduction in other forums is permitted,
controls regulatory T cell function and is inhibited by TNF-α in rheumatoid provided the original author(s) and the copyright owner(s) are credited and that the
arthritis. Nat Med. (2013) 19:322–8. doi: 10.1038/nm.3085 original publication in this journal is cited, in accordance with accepted academic
132. Westhovens R, Robles M, Ximenes AC, Nayiager S, Wollenhaupt J, Durez P, practice. No use, distribution or reproduction is permitted which does not comply
et al. Clinical efficacy and safety of abatacept in methotrexate-naive patients with these terms.

Frontiers in Immunology | www.frontiersin.org 11 April 2019 | Volume 10 | Article 798