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❖ Phinney et al. (2017, Nature Reviews Molecular Cell Biology) reported that MSC efficacy often

results from immune modulation and trophic signaling, not just cell count. Highlights trophic
effects and immune modulation over sheer cell number.
❖ Yáñez-Mó et al. (2015, Journal of Extracellular Vesicles) described the dose-sensitive nature of
exosome-mediated signaling, noting that a physiological range is key for safety and efficacy.
Emphasizes the dose-sensitive role of exosomes in intercellular communication.

Fresh MSCs and MSC-derived exosomes are most effective when delivered in biologically appropriate,
controlled doses. Our high-purity, high-viability formulations require no more than 80 million cells—and
as few as 10 million—to effectively activate the body’s natural regenerative processes.

As exosome therapy gains momentum, dosing strategies that mimic natural biological rhythms—
starting slow, increasing as needed, then tapering—are proving to be both smarter and safer.

EXPECTED BENEFITS OVER TIME

Weeks 1–2: Reduced inflammation, improved energy, clearer cognition
Weeks 3–6: Enhanced sleep, immune balance, reduced joint or nerve pain
Weeks 6–12: Deeper tissue healing, skin improvements, sustained focus

6. SHIPPING, STORAGE & SAFETY

SHIPPING comes in 3 options to choose from. All packages come with cold packs.

UPS 3-Day Select – Budget Friendly option for non-urgent shipments, guaranteed delivery within 3
business days.

UPS 2nd Day Air – Faster option for time-sensitive deliveries, arrives within 2 business days.

UPS Next Day Air (NDA) – Fastest option, ensures delivery by the next business day for urgent
shipments.

Only Fresh Live Mesenchymal Stem Cells are mandatory shipped via Next Day Air
as they must be administered upon arrival. (within 48 hours of harvesting).

Why Exosomes Drops are Safe for Shipping

Exo Drops are made with sterile, purified MSC-derived exosomes in a clinical-grade salt solution.

- Not a live cell product
- No cold-chain required during shipping
- Cold packs are an added layer of care—not a necessity for safety
- Effective, reliable, and ready-to-use upon arrival

U.S. Best Stem Cells email: Info@PureMSC.com ExoDrops.com Page 8 of 9