Page 5 - Gastric pentadecapeptide BPC 157

Achilles functional index (AFI), median, minimum, maximum ferent tissues promoted by pentadecapeptidc BPC 157
[S, 12,16,17,19-21,3 11. Therefore, this study usefully re-
cords yet another tissue in which this pentadecapeptide
facilitates healing. Vice versa, a suitable generalization,
without side effect presenting with other peptides is very
possible. For instance, OP- 1 [S] induces ossicles-forma-
tion in Achilles tendon tissue. Contrary, BPC 157 ac-
celerates tendon-healing, has strong osteogenic effect in
non-union model [16], heals deep partial thickness skin
burn [12], but does not induce ossicles-formation in
tendon tissue. Besides, the accelerated repair without
carrier addition is particularly relevant for healing
1 2 3 4 5 6 7 8 9 1011121314 delivery presenting effect either given locally or systemi-
DAY cally [8,12,16,17,19-21,311. This is an important depar-
a Control vs BPC ny p<O 01
b Control vs BPC mg pc0 01 ture from management of tendon injury that comprises
C Healthy vs BPC my p<O 013 Healthy vs BPC my IS significant (p<O 012) peptides. Regardless commonly suggested physiologic
for any time point except 13th and 14th day importance [1,4,5,9,14,24,25], other peptides, alone not
Fig 1 Rcit Achilleh tendon trnnaection Functional evaluation .4FI active, need addition of collagen matrix or other carrier
daily ase~ed Agents (lkg b M. , i p . once time dnily) (g'ijtric penta- (for review see, i.e. [10,14,24,25]). Making a peptide+
dec'ipeptide BPC 157 (10 big. 10 ng or 10 pg) or saline (5 0 nil)), carrier(s)-complex a5 dual effect may provoke method-
were fiidy applied 'it 30 inin after surgery, the last application 'it OlogicaVactivity dilemmas (i.e., [24]), however, not
24 h before 'iutopsy Median/Miiiimuni/Mnximiim (MedlMinlMnx) avoiding limited delivery regularly inappropriate for
KI usk~llLWdli~ and Mdiln Whitney tests (due to Bonfeironi coirec-
tion. the vnlues of p < 0 016 or less weie considered to be stcitistically routine use. Native to tendon, IGF-I, with binding pro-
relev'int) (vj control with trnnsected tendon (0)-(a) BPC 157 ng (+), teins keeping it more stable and locked in the matrix
(b) BPC 157 cig (01, nornicil healthy rat? (A) diferent liom all gioup\, [24,25], can drive collagen synthesis, still needs variant
at
except to BPC 157 pg (0) pojt-operative day 13 and 14) form (the recombinant LR3-IGF-I), carrier, and injec-
tion into the wound [lo]. Likewise, GDFs 5,6,7 need
and the cellular events in tendon injuries well charac- collagen sponges in the tendon defects [l]. Basic fibro-
terized (for review see. i.e., [3,18]). Supportingly, a blast growth factor (bFGF) in vitro cultured rat patellar
suitable background presents healing in variety of dif- tendon fibroblasts accelerated wound closure in lower

Fig. 2. Microscopic appearance. Transected rat Achilles tendon (T), presentation at resection margin (RM), reticulin fibers (RF) (post-operative day
4. Gomori silver slain, magnification 40x, upper) denser and more regular distribution in pentadecapeptide BPC 157 rat (pg-group, upper, right);
collagen fibers (CF) (post-operative day 7. Mallory threechroine stain, magnification 25x. lower), low but definite presence of mature collagen (CF),
cellularity still relatively high, some young capillaries emerging (c) (control, lower, left); large fields of dense. inatLire collagen (CF). lower cellularity,
well formed capillaries and small vessels (v) (gastric pentadecapeptide BPC 157 iig-group, lower, right).