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1434 uMSC Exosomes Suppress Scar Formation
Figure 5. uMSC-Exo-specific microRNAs target the TGF-b/SMAD2 pathway to suppress myofibroblast formation. (A): The effect of
uMSC-Exo-specific miRNAs on TGF-b-stimulated SMA expression. The miRNAs were overexpressed using agomirs. Data are presented
as mean 6 SD; n =3; pp, p , .01. (B): A list of predicted binding sites of uMSC-Exo-specific miRNAs and their targets. (C): Luciferase
reporter assay showing exosomal miR-21, miR-23a, miR-125b, and miR-145 regulates the target gene reporters’ luciferase activities.
Data are presented as mean 6 SD; n =4; pp, p , .01; ppp, p , .001. (D): Western blot analysis showing the effect of exosomal miR-
(Figure legend continues on next page.)
©AlphaMed Press 2016 STEM CELLS TRANSLATIONAL MEDICINE
