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P U P P Y P A C K

HUU Testing
Hyperuricosuria is characterized by elevated levels of uric acid in the urine. This disease predisposes
dogs to form stones in their bladders or sometimes kidneys. The trait can occur in any breed but is most
commonly found in the Dalmatian, Bulldog and Black Russian Terrier where Dalmatians are

homozygous for hyperuricosuria.

Sire Dam Offspring

Clear + Clear = 100% Clear IDEAL

Clear + Carrier = 50% Clear + 50% carriers - ACCEPTABLE

Clear + Affected = 100% carriers - ACCEPTABLE

Carrier + Clear = 50% Clear + 50% carriers - ACCEPTABLE

Carrier + Carrier = 25% clear + 25% affected + 50% carriers (DO NOT BREED)

Carrier + Affected = 50% carriers + 50% affected (DO NOT BREED)

Affected + Clear = 100% carriers - ACCEPTABLE

Affected + Carrier = 50% carriers + 50% affected (DO NOT BREED)

Affected + Affected = 100% affected (DO NOT BREED)

Clear

Genotype: N / N [ Homozygous normal]

The dog is noncarrier of the mutant gene. The dog will never develop Hyperuricosuria and therefore it
can be bred to any other dog.
Source: Laboklin UK www.laboklin.co.uk

Carrier
Genotype: N / HU [ Heterozygous ]
The dog carries one copy of the mutant gene and one copy of the normal gene. The dog will never
develop Hyperuricosuria but since it carries the mutant gene, it can pass it on to its offspring with the

probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because
25% of their offspring is expected to be affected (see table above).
Source: Laboklin UK www.laboklin.co.uk

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