Page 59 - CASA Bulletin of Anesthesiology 2022; 9(5)

Vol. 9, No 5, 2022

缩宫素是治疗产科宫缩乏力的首选，其加强子宫收缩、迅速关闭子宫肌层创面的血窦、阻断

血流的效果确切，但缩宫素有其固有的副作用，通过直接（包括反射）作用或间接作用可导致产
妇显著短暂的低血压、心动过速和/或心律失常，缩宫素还有直接抑制心脏收缩力及导致冠脉痉挛
的作用。对于心肺功能较差的产妇无相应的代偿性反应，尤其对于肺动脉高压者，往往会导致体

肺压力倒置，出现肺高压危象。同时胎儿的娩出和缩宫素的应用，子宫血窦内的血液回流至体循
环，回心血量骤然增加，右心难以承受前负荷的突然增加，会即刻出现右心衰竭。

缩宫素的心血管副作用同剂量相关，目前研究认为，以<5U/次缓慢滴注，或以一定剂量稀释
后静脉滴注，对血流动力学影响较轻。

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