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Sterile inflammation may result from retained intraocular foreign material like cotton
                fibers, from toxic reaction to drugs or irrigating fluids, from operative trauma, from

                exacerbation of preexisting uveitis, and from other conditions like phacoanaphylactic
                endophthalmitis and sympathetic ophthalmia. Post trauma or post cataract surgery severe
                inflammation with true hypopyon can result from retained lens fragments.
                Ultrasonography may be helpful in establishing the diagnosis. The clinical presentation
                depends on cause, therefore the history may be helpful, and should include the details of
                recent surgery, allergy history and uveitis history.


                IV.  PREVENTION AND COUNSELING

                The  mainstay  of  prevention  of  post  operative  endophthalmitis  is  maintenance  of  strict
                surgical  asepsis during any  intraocular  surgery.      The  ocular  surface  and  adnexa  are the
                primary sources of microbes in culture positive cases of post operative endophthalmitis.
                The  use  of  topical  5%  povidine  iodine  solution  in  the  conjunctival  fornices  before

                performing intraocular surgery reduces the bacterial load and decreases the incidence of
                this  condition. The  second  line of prevention  is  use  of broad  spectrum  and  bactericidial
                topical / periocular/ intracameral  antibiotics. Numerous surgical studies have confirmed
                that  prophylactic    antibiotics  are  maximally  effective  preoperatively  and  less  effective
                postoperatively in preventing endophthalmits.  In case of post operative endophthalmitis,
                prompt  referral  to  a  tertiary  care  centre  in  case  of  slightest  doubt  is  mandatory.
                Investigations have to be immediately performed to rule out any intra ocular foreign body.


                V.  OPTIMAL DIAGNOSTIC CRITERIA, INVESTIGATIONS, TREATMENT
                     & REFERRAL CRITERIA


                *Situation 1: At Secondary Hospital/ Non-Metro situation: Optimal

                Standards of Treatment in Situations where technology and resources
                are limited


                a) Clinical Diagnosis:

                The diagnosis of endophthalmitis is based on the clinical presentation, be it postoperative,
                post-trauma  or  endogenous.  Any  eye  with  inflammation  greater  than  the  usual
                postoperative  or  post-trauma  clinical  course  should  be  suspected  of  having
                endophthalmitis. Symptomatically, typically the patient notes a sudden increase in pain and



                decrease  in  vision  which  may  manifest  after  a  variable  time  period  after  an  intraocular
                surgery  or  open  globe  injury.  Examination  demonstrates  conjunctival  chemosis  and

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