Page 3 - The Hemophilia Times 2.0_Neat
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The therapy option available

                                                                                                for hemophilia A is factor VIII
                                                                                                 replacement therapy which
                                                                                                can be either plasma-derived                                      FVIII product type                                    Product name (manufacturer)
                         For PwH A without Inhibitor       Product Name (Manufacturer)                                                                                                                                                                              4 weeks
                                                                                                        or recombinant
                                                            Hemofil M (Takeda[Shire]),
                            Plasma-Derived FVIII            Immunate (Takeda[Shire]),                                                                                                                 HEMLIBRA
                                                     Hemorel A (Reliance), Factocel VIII (Intas)                                                                                                    has a half-life of
                                                                                                                                                                    Recombinant                                   10
                                                           Recombinate (Takeda[Shire]),                                                                                 FVIII                          4 WEEKS
                             Recombinant FVIII
                                                             NovoEight (Novo-Nordisk)



          What are the current therapy
           options available for PwH A?                                                                                                                             What is the half-life of HEMLIBRA?























                                                                                                The therapy option available
                                                                                                  for patients with inhibitor
                          For PwH A with Inhibitor        Product Name (Manufacturer)                                                                                                  Loading dose: 3 mg/kg once weekly                                HEMLIBRA is administered as
                                                                                                     is aPCC or factor VII
                              aPCC (activated                                                                                                                                                                 for the first 4 weeks                 once-weekly subcutaneous injection
                           prothrombin complex               FEIBA (Takeda[Shire])
                                concentrate)                                                                                                                                           Maintenance dose: 1.5 mg/kg once weekly



                                 Factor VII                 NovoSeven (Novo-Nordisk)                                                                                    What is the recommended

                                                                                                                                                                            dose of HEMLIBRA?


                      What are the current therapy options
                       available for PwH A with inhibitors?














                                                                                                                                                 For internal use only                                                                                                                               For internal use only
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