Page 12 - Bio Rex NONI Booklet

glycosides iridoids, lignan components) to inhibit blood LDL-

oxidation toxicity, a key atherogenic factor, which has been

attributed to both a direct free radical scavenging activity of

the preparation, and to its marked lipoxygenase and

cyclooxygenase activities. NONI also exerts a direct protective

effect on endothelial cells from the cytotoxic hydroperoxides

produced by extensive LDL oxidation. Notably, damnacanthal,

a trace anthraquinone component of NONI fruit, has been

shown to contribute to BIO REX® NONI remarkable anti-

inflammatory action through the suppression of nuclear

factor-kB (NF-kB) activity response, with resulting inhibition

of the expression of pro-inflammatory cytokines,

cyclooxygenase-2, and inducible nitric oxide synthase.

Type 2 diabetes is associated with increased glucose

production due to the inability of insulin to suppress hepatic

gluconeogenesis and promote glycolysis. Insulin inhibits

gluconeogenesis by modulating transcription factors such as

forkhead box O (FoxO1). A specific research published in the

British Journal of Nutrition concluded that supplementation

with Fermented NONI (fNJ) inhibited weight gain and

improved glucose and insulin tolerance and fasting glucose

in animal study model. The research data suggest that

Fermented NONI improves glucose metabolism via FoxO1

regulation in diabetic patients.

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