Page 103 - ebook HCC

EASL
GENEVA, SWITZERLANDA, SWITZERLAND
PROGRAMME
101
100
100 PROGRAMME AND ABSTRACTSAND ABSTRACTS GENEV EASL HCC SUMMITHCC SUMMIT 101
FEBRUAR
FEBRUARY 13 - 16, 2014Y 13 - 16, 2014

Geographical Regions/ North India (25) South India (25) North East India (25) North India (5) South North East
Types of patients → India (5) India (5)

↓Genes and HCC Asymptomatic HBV carriers
Parameters(Total number (Numbers inside bracket indicate percentage of cases) (Numbers inside bracket indicate percentage of cases)
of mutation)
Surface Gene (1) 132 stop codon (52) 132 stop codon (16) 132 stop codon (16) 132 stop codon (20) ND ND
Pre S1[aa1-aa119] ND ND ND ND ND ND
Pre S2 [ aa119-aa174] √ (52) √ (16) √ (16) √ (20) ND ND
Major Surface [aa174- ND ND ND ND ND ND
aa400]
Inside a and MHR
First loop (aa 124-aa 137) ND ND ND ND ND ND
Second loop (aa139- aa √ (52) √ (16) √ (16) √ (20) ND ND
147)
Outside a and MHR ND ND ND ND ND ND
X gene (23) 31 SàA 76 78 SàC 89 135 31 33 78 89 LàV 31 33 PàS 78 89 98 135 31 SàA 135 113 139 HàE ND ND
(12) AàS (12) LàV GàS SàA PàS SàC (20) SàA (12) SàC LàV(12) Làdeletion GàS (20) GàS Kàstop (20)
(20) (12) (12) (12) (20) (20) (12) (12) (12) (12) (20) (20)
Regulatory domain (aa 1- √ √ ND ND ND √ √ ND ND √ √ ND ND ND ND √ ND ND ND ND ND
BASIC POSTER ABSTRACTS XAP binding region (aa 178→deletion (100) ND 270S→F √ ND ND ND ND 178→deletion 267 IàN ND 268 DàT (12) ND 178→deletion ND 270S→F ND ND ND BASIC POSTER ABSTRACTS
aa 48)[ Strongly conserved
region]
ND
ND
√
ND
√
ND
ND
√
√
√
ND
√
61- aa 91)
ND
ND
√
√
P 53 binding region (aa
ND
ND
ND
√
ND
ND
√
ND
ND
ND
ND
101- aa 153)
Polymerase gene (15)
ND
178→deletion
ND
ND
ND
Primase (aa 1-aa 178)
√
√
ND
√
√
ND
ND
Spacer (aa 178-aa 304) ND (24) (20) (4) (12) ND (20) (20) ND ND
ND
ND
√
√
√
ND
√
Catalytic determinant NS NS NS NS NS NS NS NS NS NS
(A-H)(aa 336-aa 680)
RNase(aa 680-aa 838) NS NS NS NS NS NS NS NS NS NS
Pre Core/Core (60) 10 IàL 28 92 120 96 NàT 10 41 SàT 92 109 10 IàL (16) 28 148 LàS 155 IàT 161 YàN 93 EàD 109 120 VàT (60) ND 10 IàL 30
(76) WàStop VàG VàT (92) IàL (36) VàG(36) AàI(36) wàstop (28) (40) (28) (100) AàV (20) MàR
(20) (88) (88) (36) (16) (60) (20)
Amino terminal (aa 1- aa √ √ √ √ √ √ √ √ √ √ √ ND ND ND √ √ √ ND √ √
150)
Carboxyl terminal(aa 150- ND ND ND ND ND ND ND ND ND ND ND √ √ √ ND ND ND ND ND ND
aa 179)
Reliability of Phylogenetic approach to detect the HBV genotype
Based on X gene √ √ √ √ √ √
Based on P gene √ √ √ √ √ √
Based on C gene √ √ √ √ √ √
Based on S gene √ √ √ √ √ √