Page 264 - ebook HCC

PROGRAMME AND ABSTRACTSAND ABSTRACTS
EASL HCC SUMMITHCC SUMMIT
GENEVA, SWITZERLANDA, SWITZERLAND
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262 PROGRAMME GENEV EASL 263
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FEBRUAR
FEBRUARY 13 - 16, 2014Y 13 - 16, 2014
Poster Board Number C44
GAMMA GLUTAMYL TRANSPEPTIDASE (GGT):
IS THERE ANY CORRELATION BETWEEN GGT
AND ALPHA-FETOPROTEIN (AFP) LEVELS IN
CIRRHOTIC PATIENTS WITH HEPATOCELULAR
CARCINOMA?

Renato F. Da Silva , Cibele M. de Oliveira , Patrícia D. S. F. Pereira , The patients were dichotomized according to GGT cutting level = 166 UI/L (Classification
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Paulo C. Arroyo Júnior , Willian J. Duca , Helen C. C. de Felício , Tree). Among the patients with GGT<= 166 UI/L, median AFP value (variation) was
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João Paulo C. do Amaral , José Eduardo P. Monteiro , , Rita D. C. M. A. da Silva 1 41,5 ng/ml (1,1 – 100.672,00) and among those with GGT > 166 UI/L was 180 ng/ml (
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1 Faculty of Medicine of São José do Rio Preto, São José do Rio Preto, Brazil 2,4- 219.200,00), p= 0,014. There was no difference among the diameter of the largest
nodule between the two groups: median 4,6 cm (0,6-26) and median 5 cm (2- 15,4) to
Corresponding author’s e-mail: renatosilva@famerp.br GGT<= 166 UI/L and > 166 UI/L, respectively, p = 0,11.
Conclusion: Our data identified a cutoff value that showed interaction among GGT and
Introduction: The alpha-fetoprotein (AFP) is currently used as prognosis in HCC. Some AFP. When GGT were greater than 166 UI/L the AFP values were significantly higher
studies suggest that serum gamma glutamyl transpeptidase levels (gGT) can also have compared to patients with lower GGT. The clinical significance of this finding can’t be
this role. We want to know whether there is interaction among the values of GGT and explained from this analysis. Therefore the analysis of other variables can clarify the
AFP in cirrhotic patients with HCC in order to investigate the possible role of GGT in this role of GGT in patients with HCC.
context.

Aims: To analyze the correlation between gGT and AFP levels in cirrhotic patients with
hepatocellular carcinoma.
Methodology: Retrospective study of patients with diagnosis of hepatocellular
carcinoma, from 1998 to 2012, in a School Hospital. The studied variables were:
CLINICAL POSTER ABSTRACTS variables. The Mann-Whitney test was used to compare the continuous variables with CLINICAL POSTER ABSTRACTS
gender, age, tumor diameter, number of nodules and Edmondson-Steiner histology
classification. Classification Tree was applied to verify possible interaction among the

non normal distribution.
Results: The records of 277 patients with hepatocellular carcinoma were reviewed.
Male gender was 84,5% and the mean age was 57 years old. The Edmondson-Steiner
histology classification (degree 1 to 4) showed this distribuction: G1=33,3 %, G3= 56,9%
and G4 = 9,8%. The number of nodules was: 1- 64,6%, 2- 10,2%, 3 - 3,4% and multiple
nodules -21,8%. The median AFP value was 60,7 ng/ml (ranging from 1,1 ng/ml to
219.200,00 ng/ml). The median GGT value was 124,5 UI/L ( ranging from 10 UI/L to
967 UI/L).