Page 268 - ebook HCC

GENEV
PROGRAMME
EASL HCC SUMMITHCC SUMMIT
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266 PROGRAMME AND ABSTRACTSAND ABSTRACTS GENEVA, SWITZERLANDA, SWITZERLAND EASL 267
FEBRUAR
FEBRUARY 13 - 16, 2014Y 13 - 16, 2014
Poster Board Number C46
VASCULAR ENDOTHELIAL GROWTH FACTOR
GENETIC VARIANTS RELATED TO GENDER
IN HEPATOCELLULAR CARCINOMA AND
CIRRHOSIS: PRELIMINARY RESULTS

Victor Nogueira , Rita C. M. A. da Silva , Renato F. Da Silva , Rafael F. Ferreira , Results: The homozygous wild genotype (CC) was highlighted in all groups (G1=67.3%,
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Marcela A. D. S. Pinhel , Graciele D. Tenani , Michele L. Gregório , Willian J. Duca , G2=75.8% and G3=72.0%, P>0.05), as well as the allele C (G1=0.84, G2=0.87
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Joao G. da Silva Castro Andrade , Erika Yuki Yvamoto , Paulo C. Arroyo Júnior , and G3=0.82, P>0.05). The CC genotype was more frequent in female on G3 (78%),
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Helen C. de Felicio , Marcelo A. Nakazone , Dorotéia R. S. Souza 2 compared to female with HCC on G1 (67% P=0.026). The presence of -/T genotype were
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1 Clinical Department , Surgery Department, Nurse Department, Faculty of Medicine of more frequent in male patients on G2 (75%), in comparison with G3 (40%, P=0.044). The
São José do Rio Preto, São José do Rio Preto, Brazil comparison among patients with HCC and Cirrhosis and also HCC and healthy patients
showed no difference for the -/T genotype (P= 0.231 and P=1.0, respectively). Alcoholism
Corresponding author’s e-mail: renatosilva@famerp.br was more frequent among G2 (46.3%), compared to G3 (21%, P=0.0005). Diabetes was
more frequent among G1 (35%) and G2 (35%), related to G3 (1%, P=0.0001).
Introduction: Hepatocellular carcinoma (HCC) is the most common liver cancer with risk Conclusion: VEGF genetic variants, by itself, are not associated with HCC or Cirrhosis.
factors as cirrhosis secondary to B and C hepatitis, nonalcoholic steatohepatitis, alcohol, However, the CC genotype showed significant association with healthy females, while the
besides genetic alterations. In this context, the vascular endothelial growth factor (VEGF) presence of the -/T genotype showed association with cirrhotic male patients. Our data
is associated to the carcinogenic process. suggest association of cirrhosis with diabetes and alcoholism as well as for -/T genotype
in male gender. The number of patients in this study limits major clinical conclusions. The
Aims: Evaluate the association of C936T-VEGF polymorphism with HCC and Cirrhosis, continuation of this study with more patients will contribute to the better understanding
and its association with gender, and also clinical and epidemiologic variables. about the role of the VEGF polymorphism on hepatic carcinogenesis.
Methodology: We studied 232 individuals with age between 8 and 92 years old, distributed
in 3 groups: G1- 34 patients with HCC (19 males and 15 females); G2- 95 patients with
CLINICAL POSTER ABSTRACTS were: G1 – HVC: 5, HVB: 2, HVC + alcohol: 3, alcohol: 5, miscellaneous: 8; G2 - HVC: CLINICAL POSTER ABSTRACTS
cirrhosis without HCC (71 males and 24 females); e G3- 104 healthy individuals in the
control group (36 males and 68 females). The causes of cirrhosis in the studied groups
26, HVB: 5, HVC + alcohol: 18, alcohol: 28, miscellaneous: 18. The VEGF variants were
analyzed by PCR/RFLP. The variables analyzed were gender, alcoholism, diabetes,
systemic arterial hypertension and genotype. We used Fisher’s exact test or Chi-Square,
with significance level P<0.05.