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3.3 – What Durable Biologics Would

Actually Look Like

If we took immune compatibility seriously—if it were built
into the blueprint instead of treated as an afterthought—
biologics would look fundamentally different than they
do today.

They wouldn’t be designed purely for potency or
pharmacokinetics.
They’d be designed for permanence—for resilience in the
face of an immune system that is constantly assessing,
adapting, and remembering.
They’d be built not just to work, but to keep working—
without provoking rejection, escalation, or switch.

So what does that look like in practice?

It starts with how the drug is introduced.

Instead of defaulting to intravenous or subcutaneous
delivery—routes the immune system interprets as injury or
invasion—immune-compatible biologics would favor
oral or mucosal pathways. These aren’t just convenient.
They’re immunologically strategic.

The gut, after all, isn’t just a digestive organ. It’s the largest
immunological training ground in the body—home to
nearly 70% of the immune system’s total mass. And unlike
the bloodstream or skin, the gut isn’t calibrated for defense.
It’s calibrated for discernment.

Every day, the gut immune system processes thousands of
antigens from food, microbes, and environmental
exposures—and it does so without triggering full-blown

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