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Key
Why It
Concept Definition Indicators/Outco
Matters
mes
Provides
Co-culture early,
drug mechanistic
Ex vivo candidates insights CD86/MHC-II
Assays for upregulation
Dendritic Cell with antigen- into (activation) vs. IL-
presenting
whether a
Activation cells to molecule 10 production and
and Treg observe induces Treg induction
Induction (tolerance)
immune immune
interpretation activation
or tolerance

Extend Helps
preclinical detect
studies to delayed ADA levels,
Animal capture immunogen lymphoid
Models for immune icity issues profiling,
Long-Term rejection that might Treg/effector T
Immune over time, be missed cell ratios over
Response
not just in short- extended durations
initial term
efficacy models
Enables
Use AI and early
structural reengineeri
Predictive biology to ng or Detection of non-
Algorithms identify risk- elimination human glycans,
for prone of high-risk unstable regions,
Immunogenic glycosylation molecules or exposed B-cell
ity Hot Spots epitopes
patterns and before
motifs clinical
testing

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