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The Immunologic Rationale

Mucosal tolerance is one of the body’s oldest immune
programs.
Every day, we ingest thousands of foreign proteins—and
our immune system ignores them. Why? Because the gut
environment is uniquely wired to tolerate, not attack,
what it sees regularly and peacefully.

Tolerizing vaccines leverage this system by:

• Delivering low-dose antigen over time
• Avoiding danger signals (e.g. adjuvants,
inflammatory carriers)
• Promoting regulatory T cell activation over
effector T cell priming
• Inducing immune memory of peace, not war

This is the opposite of conventional vaccination. And it’s
exactly what autoimmune and allergic conditions require.

A New Frontier in Preventive Medicine

Tolerizing vaccines via edible biologics are still early in
their journey—but they represent a paradigm shift in how
we think about immune error:

Not something to suppress.
But something to reprogram.

If these approaches succeed, we could be entering a future
where:

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