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Figure 2.26. I structure. A. A side view of one I structure (KCNQ1 tetramer bound to two KCNE1).
Ks
Ks
CaM is bound to helices A and B and is proximal to the KCNE1 cytoplasmic helix. The inset
(bottom left) shows the coordinate system of I (gray, side and bottom views) in the membrane
Ks
(yellow). B. An expanded view of the transmembrane S1-S6 arrangement. C. A top view (without
CaM and KCNQ1 C terminus) and (D) bottom view of I . The structural components and
Ks
identifying symbols are color-coded. S4S5L: S4-S5 linker; CaM: Apo-Calmodulin. From
Ramasubramanian and Rudy [120]. Reproduced with permission from Elsevier.