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A28    SCIENCE
                        Friday 4 May 2018

            U.S. seeking 1M for massive study of DNA, health habits



                                                                                                   testing,  initially  to  look  for  Unlike  with  most  medical
                                                                                                   so-called  "variants"  in  DNA  studies,  participants  can
                                                                                                   that affect disease risk, sim-  choose to see their own test
                                                                                                   ilar  to  what  some  private  results and share them with
                                                                                                   companies  now  sell,  Col-  their physician long before
                                                                                                   lins said. Fully mapping the  the study reaches any big-
                                                                                                   genetic code is too pricey  picture conclusions. A cau-
                                                                                                   now  for  a  million  people,  tion:  There  are  still  many
                                                                                                   but that more comprehen-     questions  about  how  best
                                                                                                   sive  approach  eventually  to use the results of genetic
                                                                                                   will be used with some par-  tests. Still, "we will try to help
                                                                                                   ticipants, too.              their  doctors  sort  through
                                                                                                   Among the first lessons Col-  what it means," Collins said.
                                                                                                   lins hopes to learn is about  One result that might bring
                                                                                                   resilience:  Why  do  some  a  quick  benefit:  Genetic
                                                                                                   people  stay  healthy  de-   variants  can  signal  who  is
                                                                                                   spite  smoking  or  pollution  prone  to  side  effects  from
                                                                                                   or poor nutrition?           more than 100 drugs, infor-
                                                                                                   "We  have  no  idea  how  mation that could be used
                                                                                                   those people escape those  to  prescribe  a  safer  drug
                                                                                                   odds," he said.              if  only  their  doctors  knew,
                                                                                                   LEARN YOUR RESULTS           Collins added.q
            In this Aug. 7, 2017, file photo, Stephanie Richurk, a nurse at the University of Pittsburgh Medical
            Center, sorts blood samples collected from participants in the "All of Us" research program in
            Pittsburgh.

            By LAURAN NEERGAARD          ready  interest:  More  than  lar — and people of all rac-
            WASHINGTON (AP) — Want-      25,000  people  got  early  es and ethnicities.
            ed: A million people willing  entry  to  the  project  over  For  now,  participants  must
            to  share  their  DNA  and  10  the  past  year  through  an  be  at  least  18.  Next  year,
            years  of  health  habits,  big  invitation-only pilot test run  the study will open to chil-
            and small, for science.      by participating universities  dren,  too.  While  there  are
            On  Sunday,  the  U.S.  gov-  and health providers.       other  big  "biobanks"  of
            ernment  will  open  nation-  WHY STUDY SO MANY?          genetic data from at least
            wide enrollment for an am-   Most  of  today's  medical  100,000  people,  the  NIH
            bitious  experiment:  If  they  care is based on what hap-  project aims to be the larg-
            can  build  a  large  enough  pened to the average per-   est  and  most  diverse  of  its
            database  comparing  the  son in short studies of a few  kind.  At  least  half  of  the
            genetics,  lifestyles  and  en-  hundred  or  thousand  pa-  participants  must  be  from   In this photo taken on Wednesday May 2, 2018, a rhino in it's
            vironments of people from  tients with a specific health  groups  traditionally  under-  enclosure in the Addo Elephant Park, near Port Elizabeth, South
            all walks of life, researchers  condition.  And  most  peo-  represented in medical re-  Africa,  on  the  eve  of  being  transported  to  Zakouma  National
            hope  to  learn  why  some  ple who volunteer for those  search, Collins stressed.     Park in Chad.
            escape  illness  and  others  studies  are  white,  leaving  GENES  AREN'T  THE  WHOLE                                          Associated Press
            don't, and better customize  questions  about  the  best  STORY
            ways  to  prevent  and  treat  care for people of different  Sure,  what  genes  you  har-  Chad gets 6 rhinos nearly 50
            disease. "A national adven-  races. "One-size-fits-all is far  bor  can  raise  your  risk  for
            ture  that  is  going  to  trans-  from  an  optimal  strategy,"  various  diseases.  But  other   years after losing the species
            form medical care," is how  Collins  said  Tuesday  in  an-  factors can increase or re-
            Dr.  Francis  Collins,  director  nouncing enrollment for All  duce some genetic risks.
            of the National Institutes of  of  Us.  The  project  involves  So first volunteers will share   Associated Press   African Parks, a Johannes-
            Health, describes his agen-  "precision  medicine,"  using  electronic  health  records   PORT  ELIZABETH,  South  Af-  burg-based  conservation
            cy's All of Us Research Pro-  traits  that  make  us  unique  and  blood  samples,  and   rica  (AP)  —  Six  critically  group,  said  Thursday  that
            gram. Congress has autho-    to  forecast  and  treat  dis-  answer  periodic  question-  endangered  black  rhinos  the  rhinos  will  travel  by  air
            rized  $1.45  billion  over  10  ease.  Learning  enough  to  naires  about  their  diet,   are being transported from  to Zakouma National Park,
            years  for  the  project.  It  all  individualize  care  requires  sleep, environmental expo-  South  Africa  to  Chad,  re-  a  reserve  in  Chad  that  it
            hinges on whether enough  studying a massive number  sures and other lifestyle fac-    storing  the  species  to  the  manages with the govern-
            people  around  the  coun-   of participants: The healthy  tors. They might wear fitness   country  in  north-central  ment.  The  group  says  the
            try will sign up, either online  and  not-so-healthy,  young  trackers and other sensors.  Africa  nearly  half  a  cen-  goal  is  to  help  the  long-
            or  through  participating  and  old,  rural  and  urban,  And  later  this  year  they'll   tury after it was wiped out  term survival of black rhinos
            health  centers.  There's  al-  blue-collar  and  white-col-  start  undergoing  genetic   there.                   and  to  restore  biodiversity
                                                                                                                                in  Chad.  It  says  there  are
                                                                                                                                fewer than 25,000 rhinos in
                                                                                                                                the  African  wild,  of  which
                                                                                                                                about  20  percent  are
                                                                                                                                black  rhinos  and  the  rest
                                                                                                                                white  rhinos.  Most  of  the
                                                                                                                                rhinos  are  in  South  Africa,
                                                                                                                                though the population has
                                                                                                                                been hit hard by poachers
                                                                                                                                supplying horns to an illegal
                                                                                                                                Asian market.q
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