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What is Venous                                                                                                                Virchow’s



              Thromboembolism (VTE)?                                                                                                        Triad                                                          BLOOD FLOW

                                                                                                                                                                                                              STASIS

                                                                                                                                            Rudolf Virchow (1821-1902) is known
                                                                                                                                            as the father of modern pathology.
             Venous thromboembolism (VTE) is a condition in which a blood clot forms most often in the                                      Virchow’s research and discoveries
             deep veins of the leg, groin or arm (known as deep vein thrombosis, DVT) and travels in the                                    are instrumental to the modern
             circulation, lodging in the lungs (known as pulmonary embolism, PE). Together, DVT and PE                                      understanding of pathological                       ENDOTHELIAL       HYPERCOAGULABILITY
                        are known as VTE - a dangerous, potentially deadly medical condition.      13                                                                                              INJURY
                                                                                                                                            treatments and human anatomy. His
                                                                                                                                            triad of thrombosis and embolism
                                                                                                                                            describes the three events necessary
                                                                                                                                            for clotting to occur. As medicine has
                                                                                                                                            evolved, the understanding of blood clots has as well, and a clear link between
                                                                                                    Embolus                                 bed rest and clotting was uncovered. Since a provoking 1944 JAMA article, the
                                                                                                 Travels to Lungs                           evils of bed rest have been well documented, and early indications of VTE as an
                                                                                                                                            “ambulatory disease” has further linked bed rest and thrombosis. More recently
                                                                                                                                            the challenges of the 2020 global pandemic have once again brought coagulation
                                                                                                                                            issues to the forefront of the medical community.



                                                                                                                                                                                      THE EVIL SEQUELAE OF COMPLETE
                                                                                                                                                                                                 BED REST                   1944, Journal of
                                                                                                                                                                                               WILLIAM DOC, M.D.            American Medical
                                                     Normal Blood Flow Deep Vein                                                                                                                   LOS ANGELES              Association
                                                                      Thrombosis                                                                                                      It is rarely possible to ascribe to bed rest alone the
                                                                                                                                                                                       disorders which become manifest in patients



                                                                                                                                            Mechanical Prophylaxis & Anticoagulants

                                              A Deadly Silent Killer

                                                                                                                                            In the hospital, blood clot prevention is attacked from two angles, thinning the blood
                                                                                                                                            through pharmacological agents and replicating ambulation to mechanically move blood
            Deep Vein Thrombosis (DVT), a thrombosis in the deep vein of the leg, is a leading cause of                                     through the circulatory system. Pharmacological therapy can have limitations with specific
                preventable hospital mortality, affecting 350,000-900,000 patients with an estimated                                        patient populations due to bleeding risk and drug-to-drug interactions.
                                  60,000-100,000 annual deaths in the United States.
                                                                                         5
                                                                                                                                            Association of periOperating Room Nurses (AORN) and American College of Chest
                                                                                                                                            Physicians (ACCP) Guidelines recommend mechanical prophylaxis for at least 18 hours
             DVTs are the fifth most common reason for hospital readmission, the third most frequent                                        per day for various patient types and prior to anesthesia for a surgical operation and
                           complication of total joint replacement (TJR), and are associated                                                immediately afterward.
                                      with an estimated annual cost of $10 billion.   5




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                                                                                                                                                                                                        MOVEMENT AND COMPRESSIONS SYSTEM
                MOVEMENT AND COMPRESSIONS SYSTEM
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