Page 43 - Rapid Review of ECG Interpretation in Small Animal Practice, 2nd Edition

Treatment of Arrhythmias

VetBooks.ir (Continued)
Boxers with the striatin mutation variably express

than one ARVC mutation in Boxers clinical disease and it is likely that there is more Striatin is a desmosomal protein (scaffolding protein) located in the intercalated disc region of the cardiomyocyte. DNA testing is available Homozygous dogs are more likely to have clinical signs and should not be used for breeding Syncope is the most common presenting sign Usually present at 4–6 years of age,

Comments • • • • • over time • • • arrhythmias • •

ECG characteristics VPCs and VT common • The typical VPC QRS morphology • is a left bundle branch block pattern (i.e., QRS in leads II, III, and aVF are predominantly positive) A subset of Boxers may • experience bradycardia-associated syncope due to sinus arrest or sinus bradycardia Similar to that of the Boxer with • ARVC VT and sudden death in 13% of • dogs VPCs and VT

Box 4.1 Breed-specific arrhythmias Genetics ARVC is inherited as autosomal • dominant trait with adult onset of disease Some Boxers have a mutation in • the striatin gene with incomplete penetrance Inherited ARVC • Genetic mode of inheritance is • undetermined Dilated cardiomyopathy (DCM) • Doberman with ventricular arrhythmias in Pinschers Doberman Pinschers inherited as au

30 Breed Boxers English Bulldog