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Chapter 1: Heart Murmurs and Gallop Heart Sounds  11


                 In small animals, gallop sounds (S 3  and S 4 ) are gener-  gallops being more prominent during light application
              ally reflective of abnormal diastolic function. As blood   of the bell of the stethoscope to the chest surface (low-
              from the atria fills the ventricles during diastole, rapid   frequency sounds). Systolic clicks are most often associ-
              deceleration of the blood column in a stiff, noncompli-  ated  with  abnormalities  of  the  atrioventricular  valves,
              ant  ventricle  (such  as  occurs  with  hypertrophic  or   such as mitral valve prolapse. In general, systolic clicks,
              restrictive cardiomyopathy) results in auscultable vibra-  and  specifically,  mitral  valve  prolapse,  are  rare  in  the   Clinical Entities
              tions.  S 3   sounds  are  generated  by  rapid  ventricular   feline population, although anecdotally such clicks may
              filling  during  early  diastole  (see  Figure  1.1).  When   be noted in cats with hypertrophic cardiomyopathy.
              present in a cat, they imply ventricular dilation and/or   Split heart sounds can also produce a triple cadence
              systolic  dysfunction.  Other  possible  causes  include   as already described and thus constitute another differ-
              hyperthyroidism and anemia. The S 4  sound is associated   ential diagnosis for gallop sounds. Asynchronous closure
              with active ventricular filling caused by atrial contrac-  of the atrioventricular valves (S 1 ) or the semilunar valves
              tion  and  occurs  late  in  diastole  (see  Figure  1.1).  S 4    (S 2 )  can  result  in  split  heart  sounds.  Split  first  heart
              sounds  are  most  commonly  ausculted  in  cats  with   sounds and split second heart sounds are very rare in
              hypertrophic cardiomyopathy. However, it is often dif-  cats. In humans and dogs, split second heart sounds can
              ficult to differentiate between S 3  or S 4  when the heart   occur with pulmonary hypertension and delay of pul-
              rate is fast, and when they merge, the result can be a   monic valve closure, but this finding has not been rec-
              single  auscultable  extra  sound,  called  a  summation   ognized  in  cats  with  pulmonary  hypertension  (see
              gallop. Summation gallop sounds occasionally can occur   Chapter  25,  “Pulmonary  Thromboembolism  and
              in  some  normal  cats  when  their  heart  rates  are  fast   Pulmonary Hypertension”).
              enough that S 3  and S 4  become audible and are super-
              imposed.  However,  in  general,  gallop  sounds  suggest   REFERENCES
              underlying structural heart disease and further diagnos-
              tic tests are warranted. Because their presence is often   Boldface font indicates key references.
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              associated with elevated left ventricular filling pressure,   cats with dynamic right ventricular outflow obstruction [abstract].
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                 Systolic clicks are a different type of third heart sound   tions with miscellaneous techniques. Clin Tech Small Anim Pract
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              with a very different causative mechanism and character.   Côté E, Manning AM, Emerson D, et al. Assessment of the preva-
              Systolic  clicks  are  short,  midsystolic  sounds  that  are   lence of heart murmurs in overtly healthy cats. J Am Vet Med
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              clicks are present, the result is a triple cadence, which can   Ettinger SJ. NT-proBNP: The cat is not a dog. Oral scientific sessions,
                                                                   28th Annual ACVIM Forum, Anaheim, CA, June 12, 2010.
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              cal  setting.  However,  the  high-frequency  sound  of  a   1398–1403.
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                                                                   2002;16:547–552.
              by  their  frequency,  with  clicks  mimicking  the  normal   Wagner  T,  Luis  Fuentes  V,  Payne  JR,  McDermott  N,  Brodbelt  D.
              heart sounds (which are high-frequency and thus more   Comparison  of  auscultatory  and  echocardiographic  findings  in
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