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320  Section H: Arterial Thromboembolism


              resting  respiratory  rate.  An  increase  in  rate  or  effort   ible loss of limb viability and necrosis requires amputa-
              should  prompt  a  reexamination  and  thoracic  radio-  tion as an alternative to euthanasia. Although the risk of
              graphs to screen for CHF. The recommended coagula-  future thromboembolic events is not altered, some cats
              tion profile testing is dependent on the treatment being   will  have  good  quality  of  life  following  amputation.
              used  and  is  discussed  with  the  specific  medications   Other cats sustain permanent flexure of their metatarsus
              above.                                             secondary to severe atrophy of their cranial tibial muscle
                                                                 group. In the University of Minnesota’s large retrospec-
                                                                 tive study, although the presence of CHF did not effect
              LONG-TERM OUTCOME AND PROGNOSIS
                                                                 survival to discharge, cats with CHF at presentation had
              Although  the  diagnosis  of  cardiogenic  ATE  carries  a   a median survival of 77 days compared to cats without
              poor  prognosis,  it  is  important  to  keep  in  mind  that   CHF at presentation, in which the median survival was
              treating  these  patients  can  still  be  fulfilling  and  may   254 days. Thus, it appears the underlying heart disease
              result in good quality of life for an extended period of   is the most common cause of death. This hypothesis is
              time. Otherwise, the outcome for a disease such as ATE   corroborated by the fact that only 20% of the cats died
              can be a self fulfilling prophecy with owners encouraged   or were euthanized due to recurrent ATE (Smith et al.
              to elect euthanasia (due to poor survival statistics) result-  2003).  Similarly,  in  another  study,  which  included  57
              ing  in  a  further  reduction  in  survival  statistics.  The   cats at risk for ATE, of the 30 deaths or euthanasias, the
              short-term prognosis depends largely on the nature and   majority were due to CHF (12) while only 4 were sec-
                                                                 ondary to recurrence of ATE (Smith et al. 2004).
              responsiveness of the underlying heart disease and heart
        Arterial Thromboembolism  poor survival times for cats with ATE (Rush et al. 2002;   REFERENCES
              failure.  Most  older  studies  have  suggested  extremely
              Laste and Harpster 1995; Moore et al. 2000). However,
                                                                 Boldface font indicates key references.
              most of these reports did not distinguish between eutha-
                                                                 Alwood AJ, Downend AB, Brooks MB, Slensky KA, Fox JA, Simpson
              nasia with no attempt to treat versus euthanasia due to
                                                                   SA, Waddell LS, Baumgardner JE, Otto CM. Anticoagulant effects
              lack of response to treatment, which is clearly an impor-
                                                                   of low molecular weight heparins in healthy cats. J Vet Intern Med
              tant comparison in a disease such as ATE with significant
                                                                   2007;21:378–387.
              bias (Smith and Tobias 2004). In one study that attempted
                                                                   signs and survival in cats with a clinical diagnosis of idiopathic
              to evaluate these differences, survival to discharge was   Atkins CE, Gallo AM, Kurzman ID, Cowen P. Risk factors, clinical
              45% when cats that did not receive therapy were excluded.   hypertrophic cardiomyopathy: 74 cases (1985–1989). J Am Vet
                                                                   Med Assoc 1992;201:613–618.
              Moreover, survival over the course of the 9-year study   Bedard C, Lanevschi-Pietersma A, Dunn M. Evaluation of coagula-
              improved over time, with a discharge rate of 73% in the   tion markers in the plasma of healthy cats and cats with asymp-
              last year reviewed (Smith and Tobias 2004).          tomatic  hypertrophic  cardiomyopathy. Vet  Clin  Pathol  2007;36:
                 Findings  that  conferred  a  better  survival  rate  were   167–172.
              having a single limb rather than bilateral limb involve-  Behrend EN, Grauer GF, Greco DS, Rose BJ, Thrall MAH. Comparison
              ment  and  continued  motor  function  at  presentation.   of the effects of diltiazem and aspirin on platelet aggregation in
                                                                   cats. J Am Anim Hosp Assoc 1996;32:11–18.
              However,  a  number  of  findings  suggest  a  more  grave   Bond BR. Fine tuning the history and physical examination: correla-
              prognosis including refractory CHF or development of   tions with miscellaneous techniques. Clin Tech Small Anim Pract
              malignant arrhythmias, acute hyperkalemia (secondary   2005;20:203–210.
              to reperfusion injury), clinical evidence of multiorgan   Brazzell JL, Borjesson DL. Evaluation of plasma antithrombin activity
              or multisystemic embolization, presence of an LA or LV   and D-dimer concentration in populations of healthy cats, clini-
              thrombus,  rising  BUN/creatinine  values,  disseminated   cally ill cats, and cats with cardiomyopathy. Vet Clin Pathol 2007;
                                                                   36(1):79–84.
              intravascular  coagulation,  and/or  unresponsive  hypo-  Bright JM, Dowers K, Powers BE. Effects of the glycoprotein IIb/IIIa
              thermia.  The  owners’  commitment  to  therapy  and   antagonist acbiximab on thrombus formation and platelet func-
              nursing care is an important factor, particularly in those   tion in cats with arterial injury. Vet Ther 2003;4(1):35–46.
              patients with declining limb viability. Notably, having a   Bright JM, Sullivan PS, Melton SL, Schneider JF, McDonald TP. The
              lower  rectal  temperature  was  a  significant  risk  factor,   effects of n-3 fatty acid supplementation on bleeding time, plasma
                                                                   fatty acid composition and in vitro platelet aggregation in cats. J
              and a rectal temperature of ≤98.9°F on admission pre-  Vet Intern Med 1994;8:247–252.
              dicted a 50% survival rate (Smith and 2004). Thus, it is   Buchanan JW, Baker GJ, Hill JD. Aortic embolism in cats: prevalence,
              valid to begin therapy, as long as the patient’s pain can   surgical  treatment,  and  electrocardiography.  Vet  Rec  1966;
              be  controlled,  taking  these  variables  into  account  and   79:496–505.
              frequently reassessing the patient’s clinical status.  Butler HC. An investigation into the relationship of an aortic embolus
                                                                   to posterior paralysis in the cat. J Small Anim Prac 1971;12:141–158.
                 Affected limbs have the potential for complete return   DeFrancesco TC, Moore RR, Atkins CE, Nolan T, Rausch WP, Sidley
              of function (Smith et al. 2004). However, rarely irrevers-  JA, Keene BW. Comparison of dalteparin and warfarin in the long-
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