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Chapter 3: Pleural Effusion  23


                                                                 however, the risk increases as greater volumes of effusion
                                                                 are removed. Therefore, some clinicians prefer to mini-
                                                                 mize this risk by removing large volumes of pleural effu-
                                                                 sion  over  separate  thoracocentesis  procedures  (for
                                                                 example, removal of 120 ml at a time and allowing the
                                                                 cat to rest for several hours or overnight before repeating   Clinical Entities
                                                                 the procedure).
                                                                   Chronic therapy to address pleural effusion is depen-
                                                                 dent  on  the  underlying  cause.  For  example,  manage-
                                                                 ment  of  heart  disease  and  congestive  heart  failure  is
                                                                 crucial in those patients with underlying heart disease
              Figure 3.4.                                        as  a  cause.  Neoplasia  may  be  addressed  with  chemo-
                                                                 therapy, radiation therapy, surgical removal, or debulk-
                                                                 ing, or some combination of these modalities. Similarly,
                                                                 underlying liver disease or protein losing nephropathy
                                                                 should  be  addressed  when  present.  Occasionally  an
                                                                 underlying cause of pleural effusion is not found and
                                                                 empirical therapy with low-dose diuretics (to slow fluid
                                                                 accumulation)  and  periodic  thoracocentesis  is  neces-
                                                                 sary. Several palliative surgical treatments are available
                                                                 if  refractory  pleural  effusion  persists  in  spite  of  these
                                                                 therapies.  These  procedures  attempt  to  provide  addi-
                                                                 tional thoracic fluid drainage or decrease pleural effu-
                                                                 sion production (Sanders and Sleeper 2004).

                                                                 REFERENCES
              Figure 3.5.                                        Boldface font indicates key references.
                                                                 Davies C, Forrester SD. Pleural effusion in cats: 82 cases (1987 to
                                                                   1995). J Small Anim Pract 1996;37:217–224.
                                                                 Fife WD, Côté E. Vet Med Today: What is your diagnosis? J Am Vet
              before  progressing  to  an  emergent  situation  in  most
                                                                   Med Assoc 2000;216:1215–1216.
              cases. Chronic pleural effusion may lead to pleural fibro-  Mandell DC. Respiratory distress in cats. In: Textbook of Respiratory
              sis and development of clinical signs with less fluid accu-  Disease in Dogs and Cats, King LG. St. Louis, 2004, Saunders,
              mulation (Fife and Côté 2000). Additionally, fluid may   12–17.
              become loculated and more difficult to remove by tho-  Rush JE, Freeman LM, Fenollosa NK, et al. Population and survival
              racocentesis over time. Medical management of conges-  characteristics  of  cats  with  hypertrophic  cardiomyopathy:  260
                                                                   cases (1990–1999). J Am Vet Med Assoc 2002;220:202–207.
              tive heart failure is discussed in Chapter 19.     Sanders NA, Sleeper M. Pleural transudates and modified transu-
                 Although  thoracocentesis  is  a  low-risk  procedure   dates.  In:  Textbook  of  Respiratory  Disease  in  Dogs  and  Cats,
              when performed by a skilled operator and with a coop-  King LG. St. Louis, 2004, Saunders, 588–597.
              erative patient, there are several possible risks including   Silverstein  DC.  Pleural  space  disease.  In:  Textbook  of  Respiratory
              lung puncture and pneumothorax, reexpansion pulmo-   Disease  in  Dogs  and  Cats,  King  LG.  St.  Louis,  2004,  Saunders,
                                                                   49–52.
              nary edema, hemodynamic collapse secondary to vagally   Weiner-Kronish JP, Goldstein R, Mathay RA, et al. Lack of association
              mediated sinus bradycardia, and bronchopleural fistula   of pleural effusion with chronic pulmonary arterial and right atrial
              (Fife  and  Côté 2000).  These  sequelae  are  uncommon;   hypertension. Chest 1967;92:967–970.
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