Page 1047 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

Cottonseed Toxicity Chapter | 68 979

VetBooks.ir supplementation (2% lysine) has been recommended Coutinho, E.M., 2002. Gossypol: a contraceptive for men.
Since cottonseed products are notably low in lysine,
Contraception. 65, 259 263.
East, E., Anderson, M., Lowenstine, L.J., 1994. Apparent gossypol-induced
when cottonseed constitutes a significant part of the diet
of growing horses and broiler chicks (Henry et al., 2001). toxicosis in adult dairy goats. J. Am. Vet. Med. A. 204, 642 643.
Fombad, R.B., Bryant, M.J., 2004. An evaluation of the use of cotton-
Iron supplementation may also be required (Henry et al.,
seed cake in the diet of growing pigs. Trop. Anim. Health Product.
2001).
36, 295 305.
Fonseca, N.B.S., Gadelha, I.C.N., Oloris, S.C.S., Soto-Blanco, B., 2013.
CONCLUDING REMARKS AND FUTURE Effectiveness of albumin-conjugated gossypol as an immunogen to
prevent gossypol-associated acute hepatotoxicity in rats. Food
DIRECTIONS
Chem. Toxicol. 56, 149 153.
Due to the advances in feed technology that have resulted Gadelha, I.C., Fonseca, N.B., Oloris, S.C., et al., 2014. Gossypol toxicity
in lower levels of gossypol in feed and greater awareness from cottonseed products. Sci. World J. 2014, 231635.
Haschek, W.M., Beasley, V.R., Buck, W.B., Finnell, J.H., 1989.
acute gossypol poisoning is now very low. However, the
Cottonseed meal (gossypol) toxicosis in a swine herd. J. Am. Vet.
more chronic effects of impaired reproduction and immu-
Med. Assoc. 195, 613 615.
notoxicity (particularly the potential effects on vaccine
Henry, M.H., Pesti, G.M., Bakalli, R., et al., 2001. The performance of
efficacy) remain a cause of substantial economic losses to
broiler chicks fed diets containing extruded cottonseed meal supple-
the livestock industries. While cottonseed products are mented with lysine. Poult Sci. 80, 762 768.
potentially useful feed sources for laying hens during Herna ´ndez-Cero ´n, J., Jousan, F.D., Soto, P., Hansen, P.J., 2005. Timing
molting, the effects of gossypol and cyclopropenoid fatty of inhibitory actions of gossypol on cultured bovine embryos. J.
acids on eggs reduces the usefulness of this relatively Dairy Sci. 88, 922 928.
cheap feed source during egg production. Holmberg, C.A., Weaver, L.D., Gutterbock, W.M., et al., 1988.
Due to the fact that removing gossypol from the plants Pathological and toxicological studies of calves fed a high concen-
via genetic/biotechnological means strips them of their tration cotton seed meal diet. Vet. Pathol. 25, 147 153.
major defenses against insect predation, current efforts Kerr, L.A., 1989. Gossypol toxicosis in cattle. Compendium on
Continuing Education for the Practising. Veterinarian. 11,
have focused on reducing the level of gossypol in cotton-
1139 1146.
seed products after harvesting and on reducing the oral
Lin, Y.C., Nuber, D.C., Gu, Y., et al., 1991. Gossypolpharmacokinetics
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in mid-lactation Brown Swiss dairy cows. Vet. Res. Commun. 15,
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