Page 1045 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

Cottonseed Toxicity Chapter | 68 977

VetBooks.ir TABLE 68.4 Summary of Selected Studies on the Effects of Gossypol on Female Reproduction

Gossypol
Species
Dose Effects Reference
Rat 5 mg/kg/day Longer diestrus Gu Y., Anderson N.O. (1985) Effects of
gossypol on the estrous cycle and ovarian
weight in the rat. Contraception. 32:
491 496
Rat 25 mg/kg/ Lower levels of estradiol-17β Lin Y.C., Fukaya T., Rikihisa Y., Walton A.
day (1985) Gossypol in female fertility control:
ovum implantation and early pregnancy
inhibited in rats. Life Sci. 37: 39 47
Rat 20 mg/kg/ Irregular and longer estrous cycles, prolonged time for Lagerlo ¨f R.K., Tone J.N. (1985) The effect of
day mating, decreased pregnancy rate, and reduced number gossypol acetic acid on female reproduction.
of viable embryos Drug Chem Toxicol. 8: 469 482
Cattle 51 mg/kg/ No interference on cycling, first service conception rate, Gambill M.D., Humphrey W.D. (1993)
day and ovarian morphology Effects of diets containing gossypol on
ovarian histology, function and fertility in
prepubertal beef heifers. Theriogenology.
40:585 593
Cattle 5 g free Reduced number of ovarian follicles .5mm Randel R.D., Willard S.T., Wyse S.J., French
gossypol/ L.N. (1996) Effects of diets containing free
animal/day gossypol on follicular development, embryo
recovery and corpus luteum function in
brangus heifers treated with bFSH.
Theriogenology. 45: 911 922

TABLE 68.5 Summary of Selected Studies on the Effects of Gossypol on Embryonic Development and Embryonic
Implantation
Species Gossypol Dose Effects Reference
Cattle 36.8 mg/kg/day free Increased number of low quality Villasen ˜or M., Coscioni A.C., Galva ˜o K.N.,
(superovulated) gossypol for 70 days embryos, fewer number of live et al. (2008) Gossypol disrupts embryo
(gossypol plasma cells per embryo, smaller embryo development in heifers. J Dairy Sci.
concentrations .7 μg/mL) diameter 91:3015 3024
Cattle 12 g/day free gossypol for Lower pregnancy rates were Galva ˜o K.N., Santos J.E., Coscioni A.C., et al.
76 days associated with harvested (2006) Embryo survival from gossypol-fed
embryos heifers after transfer to lactating cows treated
with human chorionic gonadotropin. J Dairy
Sci. 89:2056 2064
Cattle 43.5 g/day total gossypol No adverse effects Velasquez-Pereira J., Are ´chiga C.F.,
(superovulated) McDowell L.R., et al. (2002) Effects of
gossypol from cottonseed meal and dietary
vitamin E on the reproductive characteristics
of superovulated beef heifers. J Anim Sci.
80:2485 2492
Rat 5.30 μg/uterine horn Complete inhibition of embryo Lin Y.C., Rajamahendran P., Rikihisa Y.
implantation (1991) Inhibition of rat embryo implantation
in the gossypol-treated uterine horn.
Theriogenology. 35: 769 7677
Rat Delayed egg transport and Lei H.Q., Xu Y.X. (1990) Effects of gossypol
retarded early development of the acetic acid on transport and development of
embryo in the oviduct fertilized eggs in rats. Yao Xue Xue Bao. 25:
561 565