Page 1040 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

972 SECTION | XIV Poisonous Plants

VetBooks.ir TABLE 68.2 (Continued) Effects Reference

Dietary Level
Species
forward motility, sperm using selenium supplementation in
abnormalities rams. J Anim Sci. 90: 3274 3285
Goats (adult, 250 300 ppm Congestive heart failure East N.E., Anderson M., Lowenstine
dairy) 348 414 mg/animal/day I.J. (1989) Apparent gossypol-
Free gossypol induced toxicosis in adult dairy
Fed for several months goats. J Am Vet Assoc 204: 642 643
Swine 200 300 ppm Cardiac insufficiency, respiratory Haschek W.M., Beasley V.R., Buck
Free gossypol distress, mortality . 50% W.B., Finnell J.H. (1989) Cottonseed
meal (gossypol) toxicosis in a swine
100 ppm Considered “safe” herd. J Am Vet Assoc 195: 613 615
Free gossypol
Dog 5.4 5.7 mg/kg BW/day Severe congestive heart failure, Patton C.S., Legendre A.M., Gompf
Free gossypol abnormalities in myocardial R.E., Walker M.A. (1985) Heart
Duration of feeding unknown contractility failure caused by gossypol poisoning
in two dogs. J Am Vet Med Assoc
187: 625 627
Dog 20 mg/kg/day Reduced serum testosterone and Chang W.Y., Shidaifat F., Chang C.
Gossypol acetic acid estradiol-17 beta J., et al. (1996) Experimentally
induced prostatic hyperplasia in
young beagles: a model to evaluate
the chemotherapeutic effects of
gossypol. Res Commun Mol Pathol
Pharmacol. 92: 341 360
Monkey 1.5 5 mg/kg BW/day Dosing for 4 weeks (1.5 5 mg/kg Heywood R. (1988) The toxicology
(cynomolgus) (2)-free gossypol BW/day): Gastrointestinal distress, of gossypol acetic acid and
25 mg/kg BW/day (1/ 2 ) free adverse effects on body weight gain, (2)-gossypol.
gossypol negative effect on serum protein, Contraception. 37: 185 190
serum ion disturbances (including
hypokalemia), adverse effects on
reproduction.
13 weeks (25 mg/kg BW/day):
Cardiotoxicity, hepatotoxicity, renal
toxicity, and testicular damage
Monkey 4 8 mg/kg BW/day Gastrointestinal toxicity and adverse Sang G.W., Zhang Y.G., Shi Q.X.,
(rhesus) Free gossypol effects on body weight after 4 weeks et al. (1980) Chronic toxicity of
following dosing at 8 mg/kg BW/day gossypol and the relationship to its
metabolic fate in dogs and monkeys.
Zhongguo Yao Li Xue Bao. 1:39 43
Chicken 1600 mg/kg BW/day Purified Fed for 1 23 days. Weight loss, Henry M.H., Pesti G.M., Brown T.P.
(broiler gossypol 28.1% mortality, increased feed (2001) Pathology and histopathology
chicks) conversion, decreased plasma iron, of gossypol toxicity in broiler chicks.
decreased hematocrit, enlarged gall Avian Dis 45: 598 604
bladders, Severe perivascular
lymphoid aggregate formation,
biliary hyperplasia, and hepatic
cholestasis
800 mg/kg BW/day Purified Fed for 1 23 days. Weight loss,
gossypol 28.1% mortality, increased feed
conversion, decreased plasma iron,
decreased hematocrit, enlarged gall
bladders, Severe perivascular
lymphoid aggregate formation,
biliary hyperplasia, and hepatic
cholestasis
400 mg/kg BW/day Purified Fed for 1 23 days. Poor feed
gossypol conversion, mild perivascular
(Continued )