Page 1039 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

Cottonseed Toxicity Chapter | 68 971

VetBooks.ir TABLE 68.2 (Continued) Effects Reference

Dietary Level
Species
Increased erythrocyte fragility,
decreased hemoglobin levels,
increased respiratory rate
Cattle (adult) 900 1200 ppm No adverse effects Rogers G.M., Moore M.H. (1995)
Free gossypol Optimal feeding management of
Dietary source was whole gossypol-containing diets for beef
cottonseed (gossypol is extensively cattle. Vet Med 90: 994 1005
bound during digestion and is less
bioavailable)
200 600 ppm Dietary source was No adverse effects
cottonseed meal
Cattle (adult, 17.8 36.8 mg/kg BW/day Fed for 70 days. Increased number Villasen ˜or M., Coscioni A.C., Galva ˜o
dairy) Free gossypol of low quality embryos (fewer live K.N., et al. (2008) Gossypol disrupts
cells, smaller in diameter, decreased embryo development in heifers. J
blastocyst development, increased Dairy Sci. 91: 3015 3024
time to reach blastocyst stage) at
36.8 mg/kg BW/day (corresponded
to plasma gossypol concentrations of
.7 μg/mL)
Cattle (adult, $ 28.43 mg/kg BW/day Increased erythrocyte fragility Mena H., Santos J.E., Huber J.T.,
dairy) Free gossypol Tarazon M., Calhoun M.C. (2004)
The effects of varying gossypol
intake from whole cottonseed and
cottonseed meal on lactation and
blood parameters in lactating dairy
cows. J Dairy Sci. 87: 2506 2518
Cattle (adult, 951 mg/kg BW/day Fed for 170 days. Reduced Santos J.E., Villasenor M., Robinson
dairy) Free gossypol conception rates, lower pregnancy P.H., et al. (2003) Type of
rates cottonseed and level of gossypol in
diets of lactating dairy cows: plasma
gossypol, health, and reproductive
performance. J Dairy Sci. 86:
892 905
Cattle 8 mg/kg BW/day Fed for $ 28 days. Increase in Hassan M.E, Smith G.W., Ott R.S.,
(Angus, Free gossypol primary and secondary sperm et al. (2004) Reversibility of the
bulls) abnormalities (effects slowly reproductive toxicity of gossypol in
reversible after cessation of peripubertal bulls. Theriogenology.
exposure) 61: 1171 1179
Sheep 900 ppm Died from acute cardiac failure after Morgan S., Stair E.L., Martin T., et al.
(lambs) Free gossypol 3 weeks of feeding (1988) Clinical, clinicopathologic,
and toxicologic alterations
associated with gossypol toxicosis in
feeder lambs. Am J Vet Res 49:
439 493
Sheep 47 mg/kg BW/day Reduced number of viable ovarian Ca ˆmara A.C., Gadelha I.C., Borges
Free gossypol follicles (particularly primary and P.A., et al. (2015) Toxicity of
transition follicles), increased gossypol from cottonseed cake to
number of atretic ovarian follicles sheep ovarian follicles. PLoS One.
10: e0143708
Sheep $ 9 mg/kg BW/day Decreased ejaculate volume, El-Mokadem M.Y., Taha T.A., Samak
Free gossypol increased percentage dead sperm, M.A., et al. (2012) Alleviation of
decreased total functional sperm reproductive toxicity of gossypol
fraction, decreased percentage

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