Page 1077 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

Fumonisins Chapter | 71 1009

VetBooks.ir TABLE 71.1 (Continued)

Number of
Animals Dose & Route Duration Toxic Effects Reference
24 pigs 20 mg of FB 1 per kg of Up to 5 days-some pigs were All 12 pigs euthanized on days Gumprecht
BW/day, in feed euthanized each day of the 0, 1 and 2 had no lesions et al. (1998)
study
2/5 day 3 pigs and all of the
day 4 and 5 pigs had
pulmonary edema
Elevations in liver enzymes and
hepatic lesions seen on day
2—bile acids first liver
parameter to increase
6 pigs 20 mg of FB 1 per kg of 5 6 days pigs were Increased pulmonary artery Smith et al.
BW/day, in feed euthanized as they developed pressure, pulmonary artery (1999)
pulmonary edema wedge pressure and decreased
cardiac output, heart rate, and
mean arterial pressure
5 pigs Feed containing 40 ppm 4 weeks No clinical signs-gross Zomborszky
FB 1 fed ad libitum pulmonary edema evident at et al. (2000)
necropsy
5 pigs Feed containing 20 ppm 4 weeks 2 of the 5 pigs had gross Zomborszky
FB 1 fed ad libitum pulmonary edema—2 et al. (2000)
additional pigs had mild
evidence of edema present
histologically
4 pigs Feed containing 20 ppm 28 days 3 of the 4 pigs had mild Zomborszky
FB 1 fed ad libitum pulmonary edema evident et al. (2000)
histologically
7 pigs 20 mg of FB 1 per kg of 3 days Decreased left ventricular Constable et al.
BW/day, in feed contractility; heart rate, cardiac (2000)
output, and mechanical
efficiency of the left ventricle
Experimental Studies Using Naturally-Contaminated Corn Screenings
6 pigs 105 155 ppm FB 1 in Up to 28 days 3 of 6 pigs developed Harrison et al.
corn screenings fed ad pulmonary edema; liver and (1990)
libitum pancreatic lesions
8 pigs 92 ppm FB 1 in corn Up to 21 days 6 of 8 pigs developed Osweiler et al.
screenings fed ad pulmonary edema; the (1992)
libitum remaining 2 pigs were icteric
with increased liver enzymes
5 pigs 175 ppm (FB 1 1 FB 2 )as Up to 14 days 3 of 5 pigs developed Motelin et al.
corn screenings mixed pulmonary edema; (1994)
in a complete ration hepatotoxicity; decreased
weight gain
5 pigs 101 ppm (FB 1 1 FB 2 )as Up to 14 days Elevated GGT, ALT, AST, ALP, Motelin et al.
corn screenings mixed and bilirubin; liver lesions; (1994)
in a complete ration decreased weight gain
5 pigs 39 ppm (FB 1 1 FB 2 )as 14 days Histologic liver lesions Motelin et al.
corn screenings mixed (1994)
in a complete ration
5 pigs 39 ppm (FB 1 1 FB 2 )as 14 days Histologic liver lesions Motelin et al.
corn screenings mixed (1994)
in a complete ration
(Continued )