Page 1076 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

1008 SECTION | XV Mycotoxins

VetBooks.ir TABLE 71.1 Effect of Fumonisin in Pigs

Number of
Animals Dose & Route Duration Toxic Effects Reference
Experimental Studies Using Purified Fumonisin
4 pigs 0.174 0.4 mg FB 1 per 4 8 days 2 high dose pigs developed Harrison et al.
kg of BW/day, IV pulmonary edema (1990)
2 pigs 0.88 1.15 mg FB 1 per 1 pig for 4 days (0.88 mg/kg/ Mild interstitial pulmonary Haschek et al.
kg of BW/day, IV day)—2nd pig for 9 days edema histologically in 1 pig; (1992)
(1.15 mg/kg/day) hepatic lesions; pancreatic
lesions
3 pigs 4.5 6.6 mg FB 1 per kg 5 15 days 2 of the 3 pigs developed Haschek et al.
of BW/day in feed severe pulmonary edema; (1992)
hepatic lesions and mild
pancreatic lesions noted
2 pigs 0.4 mg FB 1 per kg of 12 14 days Elevated AST, GGT, bilirubin; Osweiler et al.
BW/day, IV liver lesions (1992)
8 pigs 10 ppm FB 1 added to 8 weeks Decreased weight gain Rotter et al.
the diet-fed ad libitum (1996)
Elevated cholesterol
6 pigs 1 mg FB 1 per kg of 4 days Decrease in left ventricular Smith et al.
BW/day, IV contractility and mild (2000)
pulmonary edema
Experimental Studies Using Fumonisin-Containing Culture Material
6 pigs Feeds containing 100 100 ppm diet-fed ad libitum for Elevated AST, ALP, GGT; Casteel et al.,
and 190 ppm FB 1 fed 7 days followed by 190 ppm nodular hyperplasia of the liver; 1993
ad libitum diet for 83 days histologic esophageal lesions
4 pigs Feed containing Up to 43 days Elevated bilirubin, AST, Colvin et al.
200 ppm of FB 1 fed ad cholesterol; hepatic lesions; (1993)
libitum decreased weight gain
7 pigs 16 64 mg FB 1 per kg of 3 5 days All pigs developed pulmonary Colvin et al.
BW/day as oral gavage edema within 5 days (1993)
3 pigs 4 16 mg FB 1 per kg of up to 45 days Severe hepatic disease; icterus; Colvin et al.
BW/day as oral gavage elevated liver enzymes; no (1993)
pulmonary edema
11 pigs Feeds containing 100, 6 pigs were fed 100 ppm for 10 Nodular hyperplasia of the Casteel et al.
160, and 190 ppm FB 1 days then 190 ppm for up to 83 liver; Elevated AST, ALP, GGT, (1994)
fed ad libitum days; 5 pigs were fed 100 ppm bilirubin
for 5 days and then 160 ppm Right ventricular hypertrophy;
for up to 205 days
medial hypertrophy of the small
pulmonary arteries
6 pigs feed containing 47 ppm 28 days Decreased feed consumption; Harvey et al.
FB 1 fed ad libitum Elevated AST, GGT, ALP, and (1996)
creatinine; hepatic and renal
lesions; medial hypertrophy of
the pulmonary arteries
10 pigs 20 mg of FB 1 per kg of 7 days Pulmonary edema and Smith et al.
BW/day, in feed cardiovascular abnormalities (1996a,b)
2 pigs 14.5 and 16 mg of FB 1 4 days Severe pulmonary edema; renal
per kg of BW/day, in lesions
feed
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