Page 1081 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

Fumonisins Chapter | 71 1013

VetBooks.ir TABLE 71.2 Effect of Fumonisin in Horses

Number of
Animals Dose & Route Duration Toxic Effects Reference
Experimental Studies Using Purified Fumonisin
One horse 0.125 mg/kg/day, IV 7 treatments over 9 days Leukoencephalomalacia Marasas et al.
(1988)
Elevated AST, GGT
One horse 2.5 mg/kg/day, PO 6 doses over 11 days Severe hepatosis Marasas et al.
(by gavage) (1988)
Elevated AST, GGT
One horse 1.25 mg/kg/day, PO 6 doses over 11 days Mild hepatosis Marasas et al.
(by gavage) (1988)
Elevated AST, GGT
One horse 0.1 mg/kg/day, IV and 0.1 mg/kg dose given for 16 Leukoencephalomalacia Laurent et al.
0.2 mg/kg/day, IV days then 0.2 mg/kg dose (1989)
given for 2 additional days
One horse 1.25 mg/kg to 20 doses given over 35 days Leukoencephalomalacia Kellerman
4.0 mg/kg, PO et al. (1990)
Elevated AST
One horse 1.0 mg/kg to 20 doses given over 33 days Leukoencephalomalacia Kellerman
4.0 mg/kg, PO et al. (1990)
Elevated AST, GGT
13 horses 0.01 to 0.20 mg/kg, IV Up to 10 days Leukoencephalomalacia at 0.10 and Smith et al.
0.20 mg/kg—hepatic toxicity only at (2002);
lower doses Foreman et al.
(2004)
Experimental Studies Using Fumonisin-Containing Culture Material
2 horses Diet contained 19 ppm 27 days None Schumacher
FB 1 and was fed ad et al. (1995)
libitum
2 horses Diet contained 12 and 16 days Leukoencephalomalacia Schumacher
200 ppm FB 1 and was et al. (1995)
fed ad libitum Increased GGT
2 horses 2 diets containing 65 265 ppm fed for 10 days Leukoencephalomalacia Schumacher
and 130 ppm FB 1 and et al. (1995)
was fed ad libitum 2130 ppm fed for an Increased GGT
additional 17 days
Experimental Studies Using Naturally-Contaminated Corn Screenings
4 ponies Diet contained 44 ppm 10 97 days 2 horses died with ELEM on days 10 Wang et al.
FB 1 and was fed ad and 45 2 horses were normal after (1992)
libitum 97 days
4 ponies Diets contained 238 326 days ELEM in 2 of 5 horses Wilson et al.
between 1 and 22 ppm (1992)
FB 1 and were fed ad Moderate to mild hepatosis in all
libitum 5 horses
5 ponies Diet contained 8 ppm 180 days Mild histologic lesions in the brain Wilson et al.
FB 1 and was fed ad and liver at necropsy (1992)
libitum
4 ponies Diets contained 9 120 days ELEM in all 4 ponies (day Ross et al.
between 1 and 88 ppm 9 120)—also severe hepatosis in 2 (1993)
FB 1 and were fed ad ponies
libitum

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