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1040 SECTION | XV Mycotoxins
VetBooks.ir forages, especially perennial ryegrass, are susceptible to Eriksen, G.S., Ja ¨derlund, K.H., Moldes-Anaya, A., et al., 2010.
Poisoning of dogs with tremorgenic Penicillium toxins. Med. Mycol.
infection by fungi capable of producing indole diterpene
48 (1), 188 196.
tremorgenic mycotoxins, such as lolitrems and paspali-
trems, which cause “grass staggers” in susceptible spe- Evans, T.J., Rottinghaus, G.E., Casteel, S.W., 2004. Ergot. In: Plumlee,
K.H. (Ed.), Clinical Veterinary Toxicology. Mosby, Inc, St. Louis,
cies. Although multiple mechanisms are involved in the
MO, pp. 239 243.
neurotoxicity of tremorgenic mycotoxins, impaired
Galey, F.D., Tracy, M.L., Craigmill, A.L., et al., 1991. Staggers induced
GABA- and glycine-mediated inhibitory pathways and
by consumption of perennial ryegrass in cattle and sheep from
enhanced excitatory neurotransmitter (i.e., glutamate and
northern California. J. Am. Med. Assoc. 199, 466 470.
aspartate) release appear to play major roles in the onset Gallagher, R.T., Latch, G.C.M., 1977. Production of the tremorgenic
of clinical signs. Removal of the animal from contami- mycotoxins verruculogen and fumitremorgen B by Penicillium
nated foodstuffs usually results in recovery, but severely piscarium Westling. Appl. Environ. Microbiol. 33, 730 731.
poisoned animals should be properly assessed; their tre- Gallagher, R.T., Latch, G.C., Keogh, R.G., 1980. The janthitrems: fluo-
mors and/or convulsions treated; and appropriate steps rescent tremorgenic toxins produced by Penicillium janthinellum
taken to avoid complications, such as aspiration pneumo- isolates from ryegrass pastures. Appl. Environ. Microbiol. 39,
nia. Whenever possible, animals should not have unre- 272 273.
Gant, D.B., Cole, R.J., Valdes, J.J., et al., 1987. Action of tremorgenic
stricted and unsupervised access to mold-contaminated
mycotoxins on GABA/subA/receptor. Life Sci. 41, 2207 2214.
foodstuffs.
Gao, X., Chooi, Y.-H., Ames, B.D., et al., 2011. Fungal indole alkaloid
biosynthesis: genetic and biochemical investigation of the trypto-
REFERENCES quialanine pathway in Penicillium aethiopicum. J. Am. Chem. Soc.
133, 2729 2741.
Abramson, D., 1997. Toxicants of the Genus Penicillium. In: Felix, J.P. Gordon, K.E., Masotti, R.E., Waddell, W.R., 1993. Tremorgenic enceph-
(Ed.), Handbook of Plant and Fungal Toxicants. CRC Press, Boca alopathy: a role of mycotoxins in the production of CNS disease in
Raton, FL, pp. 303 317. humans? Can. J. Neurol. Sci. 20, 237 239.
Arp, L.H., Richard, J.L., 1981. Experimental intoxication of guinea pigs Hayes, A.W., Presley, D.B., Neville, J.A., 1976. Acute toxicity of peni-
with multiple doses of the mycotoxin, Penitrem A. Mycopathologia. trem A in dogs. Toxicol. Appl. Pharmacol. 35 (2), 311 320.
73, 109 113. Hocking, A.D., Pitt, J.I., 2003. In: Hocking, A.D. (Ed.), Foodborne
Barker, A.K., Stahl, C., Ensley, S.M., et al., 2013. Tremorgenic myco- Microorganisms of Public Health Significance. AIFST Food
toxins. Compend. Contin. Educ. Vet. VetLearn. Com. E1 E6. Microbiology Group, Sydney, pp. 641 674.
Boysen, S.R., Rozanski, E.A., Chan, D.L., et al., 2002. Tremorgenic Hocking, A.D., Holds, K., Tobin, N.F., 1988. Intoxication by tremor-
mycotoxicosis in four dogs from a single household. J. Am. Vet. genic mycotoxin (Penitrem A) in a dog. Aust. Vet. J. 65, 82 85.
Med. Assoc. 221, 1441 1444. Hooser, S.B., Talcott, P.A., 2006. Mycotoxins. In: Peterson, M.E.,
Braselton, W.E., Rumler, P.C., 1996. MS/MS screen for the tremorgenic Talcott, P.A. (Eds.), Small Animal Toxicology, second ed. Elsevier
mycotoxins roquefortine and penitrem A. J. Vet. Diagn. Invest. 8, Saunders, St. Louis, MO, pp. 888 897.
515 518. Hotujac, L.J., Stern, P., 1974. Pharmacological examination of verrucu-
Breton, P., Bizot, J.C., Bull, J., et al., 1998. Brain neurotoxicity of peni- logen induced tremor. Acta Med. Iugosl. 28, 223 229.
trem A: electrophysiological, behavioral and histopathological study. Hotujac, L.J., Muftic, R.H., Filipovic, N., 1976. Verruculogen: a new
Toxicon. 36, 645 655. substance for decreasing of GABA levels in CNS. Pharmacology 14,
Burrows, G.E., Tyrl, R.J., 2001. Toxic Plants of North America. Iowa 297 300.
State University Press, Ames, IA, pp. 1 1342. Knaus, H.-G., McManus, O.B., Lee, S.H., et al., 1994. Tremorgenic
Catovic, S., Filipovic, N., Stern, P., 1975. The effect of Penitrem A upon indole alkaloids potently inhibit smooth muscle high-conductance
the level of glycine in the CNS. Bull. Sci. Sect A Yugoslavia. 20, calcium-activated potassium channels. Biochemistry 33,
284 285. 5819 5828.
Cavanagh, J.B., Holton, J.L., Nolan, C.C., et al., 1998. The effects of the Kyriakidis, N., Waight, E.S., Day, J.B., et al., 1981. Novel metabolites
tremorgenic mycotoxin penitrem A on the rat cerebellum. Vet. from Penicillium crustosum, including penitrem E, a tremorgenic
Pathol. 35, 53 63. mycotoxin. Appl. Environ. Microbiol. 42, 61 62.
Cheeke, P.R., 1998. Natural Toxicants in Feeds. second ed. Interstate Lewis, P.R., Donohue, M.B., Hocking, A.D., et al., 2005. Tremor syn-
Publishers, Inc, Danville, IL, pp. 1 479. drome associated with a fungal toxins sequelae of food contamina-
Cole, R.A., Cox, R.H., 1981. Handbook of Toxic Fungal Metabolites. tion. Med. J. Aust. 182, 582 584.
Academic Press, New York, NY. Ling, K.H., Yang, C.K., Peng, F.T., 1979. Territrems, tremorgenic myco-
Cotton, K.D., Hollywood, M.A., McHale, N.G., et al., 1997. Outward toxins of Aspergillus terreus. Appl. Environ. Microbiol. 37,
currents in smooth muscle cells isolated from sheep mesenteric lym- 355 357.
phatics. J. Physiol. 503, 1 11. Loretti, A.P., Colodel, E.M., Driemeier, D., et al., 2003. Neurological
Dalziel, J.E., Finch, S.C., Dunlop, J., 2005. The fungal neurotoxin loli- disorder in dairy cattle associated with consumption of beer residues
trem B inhibits the function of human large conductance calcium- contaminated with Aspergillus clavatus. J. Vet. Diagn. Invest. 15,
activated potassium channels. Toxicol. Lett. 155, 421 426. 123 132.