Page 1202 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition
P. 1202

and                                                   types  of             of
                                                    chloride  PCBs,                           ionophore   various  types  GC MS  anticoagulant  mycotoxins,  amanitin,  metabolites


                                       tests  tests  as  such  pesticides,  pesticides      anticoagulant  column  post  metaldehyde,  some alkaloids,  (after  glycol  nontargeted  toxins,  antibiotics,



                          Analyses     multielement  multielement  halogens  Organochlorine  pyrethroids  Organophosphate  vitamins,  (with  ethylene  alkaloids,  algal  abuse,  glycosides,  toxicants  and




                          Typical  Lead  Various  Various  Nitrate,  bromide  some          Mycotoxins,  rodenticides,  antibiotics  derivatization)  Strychnine,  pesticides,  of  drugs,  derivatization),  screens  Pesticides,  rodenticides,  of  drugs  cardiotoxic  drugs






                                                                              or                          which  volatile  which  or  or
                          of    the    the   the    and      organic  are  or  not  phosphorus  are  or  not  chemicals  not  and  acidic  proton


                      Uses  Types  in elements  table  in  elements  table  in elements  table  atoms  ionic  which  volatile  and  labile  chemicals  which  volatile  and  labile  organic  chemicals  nonpolar,  semivolatile,  labile  chemicals  sufficiently  a  attract  one

                      Common  Appropriate  Analytes  Most  periodic  Most  periodic  Most  periodic  Small  molecules  Halogenated  chemicals  nonpolar,  semivolatile,  thermally  Organic  containing  nitrogen  nonpolar,  semivolatile,  thermally  Most  Organic  fairly  are  or  thermally  Organic  are  to  basic  lose  to




                      Some      time                may      May           May              of



                      and       a  at        complex  and  matrices  confidence  confidence  structure  require  May  May  and  Fairly  interpretation  complex  the  use  interpret  specific  for  often  is
                      Disadvantages,  element  one  for  ICP-MS  expensive  complex  in  selectivity  of  lack  spectrometry.  mass  high  for  analysis  spectrometry.  mass  high  for  analysis  the  on dependant  varies.  confirmation.  preparation  sample  steps  nonvolatile,  polar,  compounds.  Data  be  can screening  equipment. expensive  to  training  properly  to  and  targeted  be  analysis








                      Advantages,  Disadvantages  analyze  only  than  sensitive  more  is Instrument  ICP-OES  analysis  level  to  due  difficult  as  selective  as  second  identification  as  selective  as  second  identification  is Selectivity  Sensitivity  analyte.  for  analysis  complex  cleanup including  for  poorly  labile thermally  instruments. expensive  nontargeted  consuming  time  very Complex,  specialized  Requires  instrumentation  must  Analysis  Quantitative  analytes.  complicated






                      Their     Can    Less     than  Low  be  Not  require  in  Not  require  in  the  second  require  Works  for  and  data.


                      With      inexpensive  sensitive  for  instruments.  compounds.  instrument.  accurate  equipment.  the  usually  for  Useful  No  required.


                      Techniques  simple     very     sensitivity             containing  Provides  compounds.  selectivity.  on depending  is  analysis  quantitation.  possible  selective.  compounds.  usually  quantitation





                      Analytical  Relatively  detection  detection,  inexpensive  simple,  Adequate  inexpensive  simple,  halogenated  for  quantitation  accurate  inexpensive  simple,  compounds  for  nitrogen.  or  inexpensive relatively  some  for  quantitation  accurate  Excellent technology.  sensitive  confirmation  accurate Provides  is  analysis  and  sensitive  of  range  is analysis  accurate





                      Various  Advantages  setup.  instrument  multielement  multielement  Relatively  instrumentation.  uses  Relatively  sensitive  Provides  Relatively  sensitive  phosphorus  quantitation  sensitivity  Provides  quite  be  No  analysis.  required.  Nontargeted  Extremely  broad  confirmation  provide



                      of        Quick  Fast  Fast        most  Very           Very          Simple,  Good  Mature  Can     very  a  Can
                      Table

                      A         absorption                                                  UV
                      81.1         spectrophotometry  chromatography  ECD  FPD              with

                      TABLE  VetBooks.ir  Technique  Atomic  ICP-OES  ICP-MS  Ion  with  GC  with  GC  HPLC  and/or  fluorescence  GC MS  LC MS/MS
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