Page 273 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

240 SECTION | II Organ Toxicity

VetBooks.ir TABLE 15.1 Incomplete List of Hepatotoxins of Veterinary Interest

Classification of
Classification
Mechanism Toxicant Source of Toxicant Source Species Affected
Free radical Carbon tetrachloride Cleaning agents Industrial All
Yellow phosphorus Fireworks Industrial All
Iron Dietary supplement Household All
Copper Dietary supplement Feed, industrial Sheep, some dog
breeds
Electrophile Aflatoxins Aspergillus spp. Mycotoxin All
Acetaminophen NSAID Household All, cats
Phenazopyridine Analgesic Household Dogs
Sesquiterpene lactones Helenium spp., Plant Herbivores
Hymenoxis spp.
Pyrrolizidine alkaloids Amsinkia spp. Plant Herbivores
Crotolaria spp.
Cynoglossum spp.
Echium spp.
Erechtites glomerulata
Senecio spp.
Biliary obstruction Sporodesmin Pithomyces chartarum Mycotoxin Herbivores, ruminants
Sapogenins Tribulus terrestris Plant Herbivores, ruminants
Panicum spp. Plant Herbivores, ruminants
Agave lecegilla Plant Herbivores, ruminants
Nolina texana Plant Herbivores, ruminants
Other Glycosides of Cycas spp. Plant Dogs
methylazocymethanol
Xylitol Sugar substitute Food, household Dogs
Carboxyatractyloside Xanthium spp. Plant Swine, herbivores
Triterpenes Lantana spp. Plant Herbivores
Amatoxins Amanita spp. Mushroom All
Microcystins Microcystis spp. Cyanobacteria All
Nodularins Nodularia spp. Cyanobacteria All
Phenolics and coal tar Disinfectants, clay pigeons Household All
derivatives
Unknown Joint supplements Drug Dogs
Idiosyncratic Sulfonamides Antimicrobial Drug Dogs
Carprofen Antiinflammatory Drug Dogs
Diazepam Sedative Drug Cats
Lomustine Chemotherapeutic Drug Dogs
Zonisamide Anticonvulsant Drug Dogs
Mitotane
Methimizole Antithyroid Drug Cats
Carbamizole Antithyroid Drug Cats