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382 SECTION | IV Drugs of Use and Abuse
VetBooks.ir and acne medications. It acts by releasing hydrogen per- Boothe, D.M., 2001. The analgesic, antipyretic, anti-inflammatory drugs.
Benzoyl peroxide is present in some topical antiseptics
In: Adams, R. (Ed.), In Veterinary Pharmacology and Therapeutics,
eighth ed. Iowa State University Press, Ames, IA, pp. 433 451.
oxide, which has antibacterial and keratinolytic effects
and promotes epithelial cell turnover. Hyperemia and blis- Borchers, A., Epstein, S.E., Gindiciosi, B., et al., 2014. Acute enteral
manganese intoxication with hepatic failure due to ingestion
tering have been reported with overuse of benzoyl
of a joint supplement overdose. J. Vet. Diag. Invest. 26 (5),
peroxide-containing products. Ingestion can lead to intra-
658 663.
gastrointestinal gas production and distension. Emetics
Boulay, J.P., Lipowitz, A.J., Klausner, J.S., 1986. Effects of cimetidine
are contraindicated if this should happen. Gastric decom-
on aspirin-induced gastric hemorrhage in dogs. Am. J. Vet. Res. 47,
pression requires use of a stomach tube. 1744 1746.
Boynton, C.S., Dick, C.F., Mayor, G.F., 1988. NSAIDs: an overview.
CONCLUDING REMARKS J. Clin. Pharmacol. 28, 512 517.
Bragg, R., Hackett, E.S., Callan, R.J., et al., 2010. Inadvertent transvagi-
AND FUTURE DIRECTIONS nal administration of sodium phosphate enemas in 2 alpaca crias.
J. Vet. Emerg. Crit. Care. 60 (6), 623 627.
OTC drugs, which are widely available to consumers,
Brater, D.C., 1988. Clinical pharmacology of NSAIDs. J. Clin.
encompass a large number of products, often contain mul-
Pharmacol. 28, 518 523.
tiple active ingredients, and have been developed for oral,
Brix, A.E., 2002. Renal papillary necrosis. Toxicol. Pathol. 30, 672 674.
topical, intraocular, intranasal, and intrarectal administra-
Brumbaugh, G.W., 2001. Adverse drug reactions and interactions in the
tion. Of the thousands of OTC drugs available, only a horse. Vet. Clin. North Am. Equine Pract. 17, 445 453.
fraction were addressed in this chapter, including some Buchweitz, J.P., Raverty, S.A., Johnson, M.B., et al., 2014. Fatal diphen-
analgesics, cold, flu, and allergy medications, and drugs hydramine poisoning in a dog. Can. Vet. J. 55, 1089 1092.
used to treat gastrointestinal symptoms. Obtaining a thor- Cantu, C., Arauz, A., Murillo-Bonilla, L.M., et al., 2003. Stroke associ-
ough history is of great importance when dealing with ated with sympathomimetics contained in over-the-counter cough
suspect OTC drug-related problems. It is often helpful if and cold drugs. Stroke. 34, 1667 1672.
the owner brings the drug container to the veterinarian as Carson, J.L., Strom, B.L., 1988. The gastrointestinal side effects of the
nonsteroidal anti-inflammatory drugs. J. Clin. Pharmacol. 28,
a source of information on the active ingredients, indica-
554 559.
tions for use, and manufacturer identification, telephone
Cathers, A.T.E., Isaza, R., Oehme, F., 2000. Acute ibuprofen toxicosis in
number, or address. Treatment for most OTC drugs
a ferret. J. Am. Vet. Med. Assoc. 216, 1246 1248.
includes decontamination, stabilization, and symptomatic Cheung, L.Y., Sonnenschein, L.A., 1983. Effect of cimetidine on canine
and supportive care with careful monitoring. gastric mucosal pH and blood flow. Am. J. Surg. 145, 24 28.
Collins, L.G., Tyler, D.E., 1984. Phenylbutazone toxicosis in a horse: a
REFERENCES clinical study. J. Am. Vet. Med. Assoc. 184, 699 703.
Collins, L.G., Tyler, D.E., 1985. Experimentally induced phenylbutazone
Adams, R.H., 2001. Autocoids and anti-inflammatory drugs. In: Adams, toxicosis in ponies: description of the syndrome and its prevention
R. (Ed.), Veterinary Pharmacology and Therapeutics, eighth ed. with synthetic prostaglandin E2. Am. J. Vet. Res. 46, 1605.
Iowa State University Press, Ames, IA, pp. 403 412. Crandell, J.M., Ware, W.A., 2005. Cardiac toxicity from phenylpropanol-
Albretsen, J.C., 2002. Oral medications. Vet. Clin. N. Amer. Small amine overdose in a dog. J. Am. Anim. Hosp. Assoc. 41, 413 420.
Anim. 32, 421 442. Daehler, M.H., 1986. Transmural pyloric perforation associated with
Allen, A.L., 2003. The diagnosis of acetaminophen toxicosis in a cat. naproxen administration in a dog. J. Am. Vet. Med. Assoc. 189,
Can. Vet. J. 44, 509 510. 694 695.
Anonymous, F.D.A. Center for Veterinary Medicine, 2015. FDA warns Dahm, L.J., Jones, D.P., 1996. Mechanisms of chemically induced liver
of illnesses and deaths in pets exposed to prescription topical pain disease. In: Zakim, D., Boyer, T.D. (Eds.), Hepatology A Textbook
medications containing Flurbiprofen. ,https://www.fda.gov/animal- of Liver Disease. W.B. Saunders Company, Philadelphia,
veterinary/newsevents/cvmupdates/ucm443333.htm. (accessed pp. 875 890.
22.05.17.). Davis, L.E., 1980. Clinical pharmacology of salicylates. J. Am. Vet.
Aronson, L.R., Drobatz, K., 1996. Acetaminophen toxicosis in 17 cats. J. Med. Assoc. 176, 65 66.
Vet. Emerg. Cri. Care. 6, 65 69. Driman, D., Wright, C., Tougas, G., et al., 1995. Omeprazole produces
Bautista, A.C., Moore, C.E., Lin, Y., et al., 2015. Hepatopathy following parietal cell hypertrophy and hyperplasia in humans.
consumption of a commercially available blue-green algae dietary Gastroenterology. 108, A87.
supplement in a dog. BMC Vet. Res. 11, 136. Dyer, F., Diesel, G., Cooles, S., Tait, A., 2009. Suspected adverse reac-
Bersenas, A.M.E., Mathews, K.A., Allen, D.G., et al., 2005. Effects of tions. Vet. Rec. 167, 118 121.
ranitidine, famotidine, pantoprazoline, and omeprazole on intragas- Ezri, T., Lerner, E., Muggia-Sullam, M., et al., 2006. Phosphate salt
tric pH in dogs. Am. J. Vet. Res. 66, 425. bowel preparation regimens alter perioperative acid base and elec-
Bolfer, L., McMichael, M., Ngwenyama, T.R., et al., 2014. Treatment of trolyte balance. Can. J. Anesth. 53, 153 158.
ibuprofen toxicosis in a dog with IV Lipid Emulsion. J. Am. Anim. Farmer, J.W., Chan, S.B., 2003. Whole body irrigation for contraband
Hosp. Assoc. 50, 136 140. bodypackers. J. Clin. Gastroenterol. 37, 147 150.