Page 737 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

702 Section |IX Gases, Solvents and Other Industrial Toxicants

VetBooks.ir molecules) by a process known as gap junctional intercel- ACKNOWLEDGMENTS
lular communication (GJIC). GJIC maintains tissue
We thank Dr. Suryanarayana Vulimiri of National Center for
homeostasis and is involved in growth, development,
and differentiation (Lau et al., 2007). Trosko and Rush Environmental Assessment of USEPA, Research Triangle Park, NC
and Dr. Ramesh Gupta of Murray State University, Hopkinsville,
(1998) suggested that loss of GJIC plays a role in carcino-
KY for their excellent comments on an earlier version of this chap-
genesis. Hu et al. (2002) showed that rats exposed orally ter. The contents of this article have been reviewed by the National
(5 mg/kg) for 3 days or 3 weeks inhibit GJIC, and GJIC Health and Environmental Effects Research Laboratory of the U.S.
is also inhibited in a dose-dependent manner in rat liver Environmental Protection Agency and approved for publication.
and dolphin kidney cell lines. However, the pathophysio- Approval does not signify that the contents necessarily reflect the
logical significance of GJIC inhibition with regard to views and policies of the Agency, nor does mention of trade names
the carcinogenic mode of action for PFOS and PFOA is or commercial products constitute endorsement or recommendation
unclear. for use.
It is important to mention that PBDEs, PFOS, and
PFOA have strong potential for reproductive and develop-
mental toxicity (Johansson et al., 2009; Abdelouahab REFERENCES
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