Page 1296 - Small Animal Internal Medicine, 6th Edition
P. 1296

1268   PART XII   Oncology


                                                                 zoledronate (at a dosage of 0.1 mg/kg administered intrave-
                   TABLE 75.2                                    nously q3-8 weeks) in dogs with tumor-associated hypercal-
  VetBooks.ir  Analgesics Commonly Used in Dogs With Cancer      cemia in which the neoplastic disease could not be surgically
                                                                 removed or that had failed chemotherapy. In most dogs,
                                                                 serum calcium concentrations were maintained within
             DRUG
                            BRAND
                                       DOSAGE
                                                                 normal limits, and no appreciable toxicity was detected.
             Nonsteroidal Antiinflammatories                     In addition, pain control has recently contributed mark-
             Carprofen      Rimadyl    1-2 mg/kg PO q12h         edly to improving the QOL in small animal cancer patients.
             Deracoxib      Deramaxx   1 mg/kg PO q24h           Opioids, nonsteroidal antiinflammatories, and other drugs
             Meloxicam      Metacam    0.1-0.2 mg/kg PO q24h     have resulted in excellent clinical results (Table 75.2).
                                                                   Finally, most cats and dogs with cancer are treated using
             Firocoxib      Previcox   5 mg/kg PO q24h
                                                                 a team approach. This team includes the pet, family, medical
             Piroxicam      Feldene    0.3 mg/kg PO q24-48h      oncologist, oncologic nurse, surgical oncologist, radiothera-
                                                                 pist, clinical pathologist, and anatomic pathologist. A smooth
             Opioids
                                                                 interaction among the members of the team results in
             Tramadol       Ultram     1-4 mg/kg PO q8-12h       marked benefits for the pet and its owner.
             Buprenorphine  Buprenex   0.01-0.03 mg/kg PO or
                                         SC q8-12h
                                                                 Suggested Readings
                                                                 Aiken SW. Principles of surgery for the cancer patient. Clin Tech
                                                                  Small Anim Pract. 2003;18:75.
            adenocarcinoma of the anal sac and metastatic sublumbar   Couto CG. Principles of cancer treatment. In: Nelson R, Couto CG,
            lymphadenopathy benefit from surgical resection of the   eds. Small animal internal medicine. 4th ed. St Louis: Elsevier;
                                                                  2009:1150.
            primary tumor and/or metastatic nodes, even if adjuvant   Eisenhauer EA, et al. New response evaluation criteria in solid
            chemotherapy  is  not  being  considered.  Removal  of  the   tumours: revised RECIST guideline (version 1.1). Eur J Cancer.
            primary mass improves clinical signs of straining in these   2009;45:228.
            patients; because the colon and rectum are compressed ven-  Lagoni L, et al. The human-animal bond and grief. Philadelphia: WB
            trally by the enlarged lymph nodes and laterally or dorsally   Saunders; 1994.
            by the primary mass, the removal of one of the lesions easily   Lynch S, et al. Development of a questionnaire assessing health-
            alleviates clinical signs. Sublumbar (or iliac) lymphadenec-  related  quality-of-life  in  dogs  and  cats  with  cancer.  Vet Comp
            tomy and chemotherapy in dogs with metastatic apocrine   Oncol. 2011;9:172.
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              Needless to say, the clinician should also address the   Page RL, et al. Clinical indications and applications of radiotherapy
            presence of paraneoplastic syndromes even if specific anti-  and hyperthermia in veterinary oncology.  Vet Clin North Am
                                                                  Small Anim Pract. 1990;20:1075.
            neoplastic therapy is not contemplated. For example, treat-  Vail DM, et al. Response evaluation criteria for peripheral nodal
            ment of hypercalcemia of malignancy with bisphosphonates   lymphoma in dogs (v1.0)—a veterinary cooperative oncology
            causes remarkable improvement in the QOL of affected dogs.   group (VCOG) consensus document. Vet Comp Oncol. 2010;8:28.
            The authors’ clinics have used pamidronate (at a dosage   Withrow SJ. The three rules of good oncology: biopsy! biopsy!
            of 1-2 mg/kg, administered intravenously q6-8 weeks) or   biopsy! J Am Anim Hosp Assoc. 1991;27:311.
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