Page 1394 - Small Animal Internal Medicine, 6th Edition

1366 PART XIII Hematology

TABLE 83.3 TABLE 83.4
VetBooks.ir Reference Intervals for Serum Chemistry Profiles in Reference Intervals for Hemostasis Profiles*
Greyhounds (n = 100) Using the COBAS c501 Analyzer*
STAGO
REFERENCE INTERVAL ACL 200 COMPACT
‡
†
PARAMETER GREYHOUNDS OSU PARAMETER (n = 88) (n = 62) OSU
OSPT (sec) 6.2-7.6 6.9-8.3 6-7.5
BUN (mg/dL) 11-21 5-20 APTT (sec) 11.2-18.1 9.7-12.1 9-21
Creatinine (mg/dL) 1.0-1.7 0.6-1.6 Fibrinogen 83.0-190.4 88.7-180.1 100-384
Phosphorus (mg/dL) 2.3-5.3 3.2-8.1 (mg/dL)
Total calcium (mg/dL) 9.4-11.4 9.3-11.6
Sodium (mEq/L) 144.0-156.0 143-153 *Determined at The Ohio State University (OSU) in Greyhounds
Potassium (mEq/L) 3.5-4.4 4.2-5.4 using an ACL 200 Coagulation Analyzer (Instrumentation
Laboratory, Lexington, MA) and Stago STA Compact CT
Chloride (mEq/L) 107.7-118.8 109-120 (Diagnostica Stago, Parsippany, NJ).
† 3.8% sodium citrate concentration tubes.
Anion gap 9.0-19.9 15-25 ‡ 3.2% sodium citrate concentration tubes.
Osmolality 285.1-310.0 285-304 From Zaldívar-López S et al.: Clinical pathology of Greyhounds and
Bicarbonate (mmol/L) 20.0-31.3 16-25 other sighthounds, Vet Clin Pathol 40:414, 2011a.
ALT (IU/L) 28.0-81.9 10-55
AST (IU/L) 24.0-57.0 12-40 better understanding of the hematologic and biochemical
ALP (IU/L) 19.0-90.0 15-120 differences between Greyhounds and non-Greyhounds, thus
ALPCAP (IU/L) 0.05-31.0 0-6 helping avoid misdiagnoses based on wrong RIs for these
CK (IU/L) 76.0-254.0 50-400 sighthound breeds.
Cholesterol (mg/dL) 91.0-210.3 80-315
Bilirubin (mg/dL) 0.07-0.3 0.1-0.4 Suggested Readings
Total protein (g/dL) 4.8-6.3 5.1-7.1 Bhatt VS, et al. Structure of Greyhound hemoglobin: origin of high
Albumin (g/dL) 2.9-3.9 2.9-4.2 oxygen affinity. Acta Crystallogr D Biol Crystallogr. 2011;67:395.
Globulin (g/dL) 1.7-3.0 2.2-2.9 Braff J, et al. Relationship between serum symmetric dimethylargi-
nine concentration and glomerular filtration rate in cats. J Vet
A/G ratio 1.0-2.2 0.8-2.2 Intern Med. 2014;28(6):1699.
Glucose (mg/dL) 77.1-121.0 77-126 Campora C, et al. Determination of haematological reference inter-
vals in healthy adult greyhounds. J Small Anim Pract. 2011;52:301.
ALP, Alkaline phosphatase; ALPCAP, steroid isoenzyme of ALP; ALT, Clemente M, et al. Serum concentrations of IgG, IgA, and IgM in
alanine aminotransferase; AST, aspartate transaminase; BUN, retired racing Greyhounds. Vet Clin Pathol. 2010;39:436.
blood urea nitrogen; CK, creatine kinase. Couto CG, et al. Acute phase protein concentrations in retired
*Roche Diagnostics, Indianapolis. racing Greyhounds. Vet Clin Pathol. 2009;38:219.
From Zaldívar-López S et al.: Clinical pathology of Greyhounds and Couto CG, et al. Evaluation of platelet aggregation using a point-
other sighthounds, Vet Clin Pathol 40:414, 2011a.
of-care instrument in retired racing Greyhounds. J Vet Intern
Med. 2006;20:365.
CONCLUSIONS Couto KM, et al. Plasma N-terminal pro-B-type natriuretic peptide
concentration in healthy retired racing Greyhounds. Vet Clin
Pathol. 2015;44(3):405.
Greyhounds have hematologic and serum biochemical Drost WT, et al. Comparison of glomerular filtration rate between
values that frequently lie outside the reference ranges estab- greyhounds and non-Greyhounds. J Vet Intern Med. 2006;20:
lished for non-Greyhounds, suggesting differences in many 544.
aspects of their physiology. For these reasons, the establish- Dunlop MM, et al. Determination of serum biochemistry reference
ment of breed- or group-specific (e.g., sighthounds) refer- intervals in a large sample of adult greyhounds. J Small Anim
ence ranges is essential for the correct diagnosis and Pract. 2011;52:4.
subsequent treatment of medical disorders based on clinico- Fayos M, et al. Serum protein electrophoresis in retired racing
Greyhounds. Vet Clin Pathol. 2005;34:397.
pathologic abnormalities. As the number of RRG adoptions Feeman WE, et al. Serum creatinine concentrations in retired
increases in the United States, veterinarians will be faced racing Greyhounds. Vet Clin Pathol. 2003;32:40.
with the challenge of interpreting laboratory parameters in Gaughan KR, Bruyette DS. Thyroid function testing in Greyhounds.
light of the hematologic idiosyncrasies of the breed. Although Am J Vet Res. 2001;62:1130.
the sample size in these studies is not as large as recom- Grützner N, et al. Evaluation of serum cobalamin concentra-
mended for the creation of RIs, approximate intervals have tions in dogs of 164 dog breeds (2006-2010). J Vet Diagn Invest.
been provided that will benefit clinicians by providing a 2012.