Page 1398 - Small Animal Internal Medicine, 6th Edition

1370 PART XIII Hematology

HIGH PCV
VetBooks.ir

High TPP (or
Normal TPP
normal RBC (or high RBC
mass) mass)
RELATIVE (i.e., ABSOLUTE
dehydration)
Blood Gases
Hypoxemia Normal PO 2
Cardiopulmonary Noncardiopulmonary
disease disease
Renal US

Renal Normal
mass/infiltration kidneys

Search for
neoplasm

Found No
neoplasm neoplasm
Serum Ep
High Low
Other Polycythemia
2ry vera

FIG 84.1
Diagnostic approach to the dog or cat with erythrocytosis. Ep, Erythropoietin; PCV,
packed cell volume; RBC, red blood cell; TPP, total plasma protein; US, ultrasonography;
2ry, secondary.

Most dogs and cats with PRV have extremely long sur- Hasler AH, et al. Serum erythropoietin values in polycythemic cats.
vival times (>2 years) if treated with hydroxyurea, with or J Am Anim Hosp Assoc. 1996;32:294.
without a phlebotomy. Because this drug is potentially Moore KW, Stepien RL. Hydroxyurea for treatment of polycythe-
myelosuppressive, complete blood counts should be per- mia secondary to right-to-left shunting patent ductus arteriosus
in 4 dogs. J Vet Intern Med. 2001;15:418.
formed every 4 to 8 weeks and the dose adjusted according Nett CS, et al. Leeching as initial treatment in a cat with polycy-
to the neutrophil count (see Chapter 75). The prognosis in thaemia vera. J Small Anim Pract. 2001;42:554.
dogs and cats with secondary erythrocytosis depends on the Noh S, et al. Renal-adenocarcinoma-associated erythrocytosis in a
nature of the primary disease. cat. Hemoglobin. 2012;11:12.
Peterson ME, et al. Diagnosis and treatment of polycythemia. In:
Suggested Readings Kirk RW, eds. Current veterinary therapy VIII. Philadelphia: WB
Beurlet S, et al. Identification of JAK2 mutations in canine primary Saunders; 1983.
polycythemia. Exp Hematol. 2011;39:542. Randolph JF, et al. Erythrocytosis and polycythemia. In: Weiss DJ,
Campbell KL. Diagnosis and management of polycythemia in dogs. Wardrop KJ, eds. Schalm’s veterinary hematology. 6th ed. Ames,
Compend Cont Educ. 1990;12:443. Iowa: Wiley-Blackwell; 2010:162.
Cook SM, et al. Serum erythropoietin concentrations measured by Sato K, et al. Secondary erythrocytosis associated with high plasma
radioimmunoassay in normal, polycythemic, and anemic dogs erythropoietin concentrations in a dog with cecal leiomyosar-
and cats. J Vet Intern Med. 1994;8:18. coma. J Am Vet Med Assoc. 2002;220:486.
Darcy H, et al. Feline primary erythrocytosis: a multicentre case Van Vonderen IK, et al. Polyuria and polydipsia and disturbed
series of 18 cats. J Fel Med Surg. 2018;20:1192. vasopressin release in 2 dogs with secondary polycythemia. J Vet
Durno AS, et al. Polycythemia and inappropriate erythropoietin Intern Med. 1997;11:300.
concentrations in two dogs with renal T-cell lymphoma. J Amer Yamauchi A, et al. Secondary erythrocytosis associated with
Anim Hosp Assoc. 2011;47:122. schwannoma in a dog. J Vet Med Sci. 2004;66:1605.