Page 766 - Small Animal Internal Medicine, 6th Edition

738 PART V Urinary Tract Disorders

VetBooks.ir Drugs Used in Dogs and Cats With Urinary Tract Disorders—cont’d DOSAGE

TRADE NAME
ACTION
DRUG
Chlorpromazine Thorazine Antiemetic 0.25-0.5 mg/kg IM, SC, PO q6-8h (after
dehydration only)
Colchicine Generic Antiinflammatory, 0.03 mg/kg/day PO (dog)
antifibrotic, inhibition of
serum amyloid A
synthesis and secretion
Cyclophosphamide Cytoxan, Immunosuppressant 50 mg/m PO q48h (dogs);
2
Neosar 200-300 mg/m PO q3wk (cats)
2
Cyclosporine Neoral, Immunosuppressant 3-7 mg/kg PO q12-24h, adjust dose via
Sandimmune monitoring
Darbepoetin alfa Aranesp Stimulates erythropoiesis 0.25-0.5 µg/kg SC once/wk adjusted
according to PCV
Diazepam Valium Skeletal muscle relaxant for 2-5 mg total dose PO q8h (dog); give
functional urethral 30 min before urination
outflow tract obstruction
Diethylstilbestrol (DES) Increases urethral closure 0.5-1 mg/dog PO; give total dose daily
pressure for 3-5 days, then titrate down to lowest
effective dose to maintain continence
(once or twice/wk)
Dimethylsulfoxide Domoso Antiinflammatory 90 mg/kg/wk SC (dogs)
Dopamine Inotropin Adrenergic (α and β 1 ) and 2-5 µg/kg/min CRI (dogs)
dopaminergic agent;
positive inotropic effect;
may increase renal
blood flow and urine
output
Estriol (Incurin) Natural Increases urethral closure Begin loading dose of 2 mg/dog PO
estrogen pressure q24h; titrate down every 2 wk to lowest
effect dose
1,25-Dihydroxycholecalciferol, Rocaltrol Active vitamin D 3 , 2.5-3.5 ng/kg PO q24h
calcitriol decreases parathyroid
hormone
Enalapril Enacard Angiotensin-converting 0.5 mg/kg PO q12-24h (dog);
enzyme inhibitor 0.25-0.5 mg/kg PO q12-24h (cat)
Erythropoietin (r-Hu-EPO), Epogen Stimulates erythropoiesis 35-50 U/kg IV, SC three times/wk or
epoetin alfa 400 U/kg IV, SC weekly; adjust dose
to PCV of 30%-35%
Famotidine Pepcid H 2 blocker 0.5 mg/kg IM, SC, PO q12-24h
Furosemide Lasix Loop diuretic 2-4 mg/kg IV, PO q8-12h
Hydralazine Apresoline Arterial vasodilator 0.5-2 mg/kg PO q12h (dog); 2.5 mg PO
q24h-q12h (cat)
Imipramine Tofranil Tricyclic antidepressant, 5-15 mg/dog PO q12h; 2.5-5 mg/cat
antimuscarinic, mild PO q12h
α-agonist activity
Lanthanum carbonate Fosrenol, Enteric phosphate binder 20-30 mg/kg/day PO given immediately
Renalzin after meals
Lisinopril Prinivil, Zestril Angiotensin-converting 0.5 mg/kg PO q24h (dog)
enzyme inhibitor
Mannitol Osmitrol Osmotic diuretic 0.5-1 g/kg as 20%-25% solution, slow IV
bolus over 5-10 min