Page 35 - BSAVA Guide to Pain Management in Small Animal Practice
P. 35

BSAVA Guide to Pain Management in Small Animal Practice



        VetBooks.ir        Dose                     Comments

            Aspirin
                                                    Used as an anti-thrombotic agent
                             mg kg every third day
            Carprofen     N A                       Not recommended
            Etodolac      N A                       Not recommended
             irocoxib     N A                       Not trialled in cats
            Paracetamol   N A                       Contraindicated
             acetaminophen
            Phenylbutazone  N A                     Not recommended
            Prednisolone   .    mg kg orally    h   Do not administer NSAIDs concurrently
             eloxicam      .  mg kg orally    h on day  ,   Indicated for pain and in ammation in chronic
                          followed by  .   mg kg orally  musculoskeletal disorders
            Robenacoxib       mg kg orally    h  up to   days   Indicated for pain and in ammation of chronic  A,
                                                    may be suitable for longer term administration
             epoxalin        mg kg day              No  A, but one study found tepoxalin was well
                                                    tolerated compared with meloxicam particularly
                                                    for urinary tract discomfort (Charlton et al.,
             olfenamic acid    mg kg orally    h  up to   days   Not indicated for chronic pain
            Vedaprofen     .  mg kg orally    h  up to   days   Not indicated for chronic pain
                  Non steroidal anti in ammatory drugs  NSAI s  and other anti in ammatory and pain relieving products
                  for use in cats with chronic maladaptive pain. Very few products have long term market authori ation
             A  and treatment must be closely supervised by a veterinary surgeon. Consult datasheets for further information.
           Use the lowest e ective dose and a multimodal approach. All NSAI s are capable of causing gastrointestinal signs
           and lesions, and hepatic and renal in ury. Regular monitoring of patients is necessary.  A   osteoarthritis.


                                                  signi cant interpatient variability in terms of
                                                  e cacy and side e ects. In animals that show a
                                                  lack of response to one NSAID, it is worth
           NSAIDs remain the most popular medications   considering swapping to another. In cases
           for treating chronic pain in dogs and cats.  hey   where a swap is made it is suggested to allow
           reduce the production of in ammatory   a   7 day washout period between the drugs
           prostaglandins by selective inhibition of the   (Kukanich et al.,   1  . Sustained release
           cyclooxygenase    C      en yme producing   formulations of NSAIDs are being developed
           a peripheral anti in ammatory e ect.   and trialled.
            urthermore, these drugs will cause a reduced
           sensitization within the CNS. Several
           formulations have market authorization for
           long term use in dogs; meloxicam is licensed
           for long term use in cats in the U  and    o attempt to reduce the potential for adverse
           guidelines have been developed for long-term   events associated with the inhibition of C
           use of NSAIDs in cats (Sparkes et al.,   1  .   en ymes, an EP4 prostaglandin receptor
           Recent studies also suggest robenacoxib may   antag onist has been studied in client-owned
           be safe in cats (King et al.,   1 ;  ing et al.,   dogs, which demonstrated improved pain relief
             1  .  here are no controlled trials   compared with placebo (Derra et al.,   16 .
           demonstrating superiority of one NSAID over   Grapiprant is planned for release in the UK in
           another in OA, and there appears to be   early   19.

           30



         Ch04 Pain Management.indd   30                                         19/12/2018   10:35
   30   31   32   33   34   35   36   37   38   39   40