Page 1014 - Veterinary Immunology, 10th Edition

As a result, the lesions may be masked by self-inflicted trauma and
VetBooks.ir secondary bacterial infection. Histologically, they are associated

with a local mast cell and eosinophil infiltration, as well as an
eosinophilia. Eosinophilic granulomas, in contrast, are not pruritic,

and present as a line of raised pink plaques on the skin. Some may
present as scattered individual crusted papules. Linear eosinophilic
ulcers (sometimes called indolent or rodent ulcers) are commonly
located in the oral cavity or on the lips. Removal of the offending

allergen may result in clinical improvement, and corticosteroid
treatment is usually of benefit. The linear form and indolent ulcers
may be difficult to treat and may require more aggressive therapy.
An idiopathic hypereosinophilic syndrome has been described in

humans, cats, and dogs. It is characterized by a prolonged,
unexplained eosinophilia, the infiltration of many organs with
eosinophils, organ dysfunction (affecting especially the heart, but
also the lungs, spleen, liver, skin, bone marrow, gastrointestinal

tract, and central nervous system), and death. An eosinophilic
enteritis may result from canine hookworm infestation.

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