Page 1025 - Veterinary Immunology, 10th Edition

blood group antigens to colonize the gut and so are much less
VetBooks.ir common in nonsecretors. Nonsecretor humans are more

susceptible to necrotizing enterocolitis and Gram-negative sepsis in
premature infants, presumably because they lack the protective

benefits of the Bifidobacteria. On the other hand, noroviruses can
also attach through these glycans when they colonize the gut, so
nonsecretors are resistant to these agents!

If blood is transfused from one animal to another, genetically
different individual, these red cell molecules will act as powerful
antigens and stimulate antibody responses in the recipient. These

antibodies cause the rapid elimination of the transfused red cells by
intravascular hemolysis by complement and by extravascular
destruction through opsonization and removal by the mononuclear

phagocyte system. Cell destruction by antibodies in this way is
classified as a type II hypersensitivity reaction.

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