Page 1052 - Veterinary Immunology, 10th Edition

• Explain why type III hypersensitivity is a feature of many viral diseases.
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Immune complexes formed by the combination of antibodies with
antigen activate the classical complement pathway. When these
complexes are deposited in tissues, the activated complement

generates chemotactic peptides that attract neutrophils. The
accumulated neutrophils may then release oxidants and enzymes,
causing acute inflammation and tissue destruction. Lesions
generated in this way are classified as type III or immune complex–

mediated hypersensitivity reactions.

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