Page 1064 - Veterinary Immunology, 10th Edition

VetBooks.ir Generalized Type III Hypersensitivity

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If an antigen is administered intravenously to animals with
circulating antibodies, immune complexes form in the bloodstream.
These immune complexes are removed by binding to either
erythrocytes or platelets, or if very large, by mononuclear

phagocytes (Fig. 32.4). If, however, complexes are produced in
excessive amounts, they are deposited in the walls of blood vessels,
especially medium-sized arteries, and in vessels where there is a
physiological outflow of fluid such as glomeruli, synovia, and the

choroid plexus (Fig. 32.5). An example of this type of
hypersensitivity is serum sickness.

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