Page 1068 - Veterinary Immunology, 10th Edition
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FIG. 32.7 The structure of a typical glomerulus. Immune
complexes may be deposited on either side of, or within, the
glomerular basement membrane.
Glomerulonephritis
When immune complexes are deposited in the glomeruli, they
cause basement membrane thickening and stimulate glomerular
cells to proliferate. Any or all of the three glomerular cell
populations, epithelial cells, endothelial cells, and mesangial cells,
can proliferate. The lesion is therefore called membranoproliferative
glomerulonephritis (MPGN). If immune complexes are deposited
only in the mesangium, mesangial cell proliferation will result in a
mesangioproliferative glomerulonephritis. MPGN lesions are
classified into three types based on their histopathology and
pathogenesis (Fig. 32.8).
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