Page 1214 - Veterinary Immunology, 10th Edition

Dogs may suffer from lymphocyte-mediated destruction of the
VetBooks.ir adrenal cortex. Affected animals present with depression, weak

pulse, bradycardia, abdominal pain, vomiting, diarrhea,
dehydration, and hypothermia. As a result of excessive sodium and

chloride loss, animals develop hypovolemia and acidosis, leading to
circulatory shock, hyperkalemia, and cardiac arrhythmias. Blood
corticosteroid levels are low in these animals. This disease has been
observed in association with hypothyroidism.

A syndrome has been described in Italian Greyhounds that
resembles autoimmune polyendocrine syndrome type 2 in humans.
This is not a random collection of unlinked diseases but a syndrome
with a common etiology but diverse clinical manifestations. It

involves mainly endocrine tissues, adrenals, thyroid, pancreas,
gonads, and skin. It tends to occur in females at mid-life.

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