Page 1229 - Veterinary Immunology, 10th Edition

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FIG. 37.6 A section from a case of canine pemphigus foliaceus.
Note the subcorneal location of the cell-filled vesicle. (Courtesy Dr. J.
Mansell.)

A mild variant of PF is pemphigus erythematosus. The lesions in

this disease tend to be confined to the face and ears and are very
similar to those of systemic lupus erythematosus (SLE). Indeed,
some dogs with pemphigus erythematosus may have antinuclear
antibodies in their serum. Panepidermal pustular pemphigus
(pemphigus vegetans) is another rare and mild variant of PF in

which papillomatous proliferation of the base of the bullae occurs
on healing.
A fifth form of pemphigus, called paraneoplastic pemphigus,

occurs in humans and has been recorded in a dog. It develops in
association with lymphoid or solid tumors. It resembles pemphigus
vulgaris, but multiple autoantibodies against skin antigens are
present.
A topical ectoparasiticide containing fipronil, amitraz and S-

methoprene has been associated with the development of an
acantholytic pustular dermatitis resembling PF. One or two
applications were sufficient to induce disease. Anti-keratinocyte

IgG was detected in the epidermis of 8 of 19 cases, while serum
anti-keratinocyte IgG was detected in 10 of 14 cases. Eleven of
fourteen dogs had detectable antibodies to desmocollin-1. Thus the
lesions closely resembled naturally occurring PF.

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