Page 1236 - Veterinary Immunology, 10th Edition

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FIG. 37.9 The basic differences between intravascular and
extravascular hemolysis.

IMHAs in dogs are classified according to the antibody class
involved, the optimal temperature at which the autoantibodies
react, and the nature of the hemolytic process (Table 37.1).

TABLE 37.1

Classification of Immune-Mediated Hemolytic Anemias

Predominant Optimal Temperatire Site of Red Cell
Class Activity Clinical Effect
Antibody (° C) Removal
I G ≫ M Agglutinin 37 Spleen Intravascular agglutination
II M Hemolysin 37 Liver Intravascular hemolysis
III G Incomplete 37 Spleen Anemia
IV M Agglutinin 4 Liver Cyanosis and infarction of
extremities
V M Incomplete 4 Liver Anemia

Class I: Caused by autoantibodies that agglutinate red cells at body
temperature. The agglutination may be seen when a drop of
blood is placed on a glass slide. Both IgG and IgM antibodies are

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