Page 975 - Veterinary Immunology, 10th Edition
P. 975
When antigen is injected into the skin of an allergic animal, two
VetBooks.ir waves of inflammation occur. There is an immediate acute
inflammatory response that occurs within 10 to 20 minutes as a
result of the release of the preformed mast cell mediators. This is
followed several hours later by a second wave called the late-phase
reaction, which peaks at 6 to 12 hours and then gradually
diminishes. This late-phase reaction is characterized by redness,
edema, and pruritus. It is believed that this late reaction results
from the release of inflammatory mediators by T cells, endothelial
cells, neutrophils, and macrophages attracted by mast cell
chemotactic factors. Th17 cells also play a role in this late process
(Chapter 14).
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