Page 982 - Veterinary Immunology, 10th Edition

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FIG. 29.18 Eosinophils release a complex array of molecules that
contribute to the acute inflammatory process. It is clear that, on
balance, eosinophils exacerbate the inflammation triggered by mast
cells.

TABLE 29.3

The Major Cytokines Produced in Type I Hypersensitivity
Reactions

Mast Cells Basophils Eosinophils
IL-3 IL-4 IL-1α
IL-4 IL-6 IL-3
IL-5 IL-4
IL-6 IL-5
IL-13 IL-6
IL-16 GM-CSF
IL-22 TNF-α
IL-25 TGF-β
GM-CSF
TNF-α
Mast cells and eosinophils interact. Thus eosinophil MBP causes
mast cells to release histamine. Mast cells in turn release eosinophil

chemotactic agents, activate eosinophils, and enhance the
expression of eosinophil receptors. Mast cells can synthesize and
secrete IL-3, IL-5, and GM-CSF, all of which promote eosinophil
degranulation, growth, and survival.

Eosinophils also play a key role in the regulation of humoral

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