Page 156 - Rule Outs in Small Animal Medicine, Problem-oriented Assessment of Problems in Physical Examination and Clinical Pathology, 2nd Edition

Basic laboratory diagnostics Basic laboratory diagnostics
Serum enzyme activities Serum enzyme activities
Rubrik Rubrik
Rubrik

VetBooks.ir

Increased AST*
Increased ALP*

Muscle cell
Haemolysis Liver cell damage
damage
Increased release Enzyme induction
from cells (only in dogs)

â True Secondary to
Pseudo- haemolysis Skeletal muscle Cardiac muscle Primary liver extrahepatic
Increased Damage to the Influence of haemolysis p. 131 cell damage cell damage disease disease
osteoclastic membrane of liver glucocorticoids/
acivity or bile duct cells anticonvulsives

– Trauma – Myocar- – Hepatitis/ – Sepsis
Prolonged – Myositis Cholangitis – Pancreatitis
– Growth – Hyperadreno- storage of whole – Muscle ditis – FIP (cat) – Intestinal
– Osteosarcoma Biliary tract Primary liver Secondary to corticism blood sample contractions – Infarction – Lymphoma barrier
– Healing of disease disease extrahepatic – Iatrogenic before (e.g. tetanus, – Hepatocellular dysfunction
fracture disease (glucocorticoid centrifugation
carcinoma
– Osteomyelitis therapy, seizures) – Hepatic lipidosis – Hypothyroidism
(dog)
phenobarbital (cat) – Hyperthyroidism
therapy)
(cat)
– Bile duct – Cholestasis (extra- – Hypothyroidism – Drug toxicity – Diabetes
(e.g. NSAIDs,
neoplasia and intrahepatic) – Diabetes
doxycycline)
mellitus
– Cholestasis – Hepatitis mellitus – Toxin (e.g. – Hyperadreno-
– FIP (cat) – Hyper- aflatoxin) corticism
– Lymphoma thyroidism – Hypoxaemia
– Hepatocellular (e.g.
carcinoma
– Hepatic lipidosis (cat) cardiovascular
disorders,
– Drug toxicity anaemia)
(e.g. NSAIDs,
doxycycline)
– Toxins (e.g. aflatoxins)
– Diabetes mellitus
– Hyperthyroidism

*

*

* Decreasesd ALP is not clinically relevant * Decreased AST activity is not clinically relevant

146 147